A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.
about
Target identification for small bioactive molecules: finding the needle in the haystack.From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties.Catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis.High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity.From noncovalent to covalent bonds: a paradigm shift in target protein identification.Affinity purification in target identification: the specificity challenge.Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery.Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe.Target identification with quantitative activity based protein profiling (ABPP).Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.A tandem isomerization/prins strategy: iridium(III)/Brønsted acid cooperative catalysisSynthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction.Diversity-oriented synthesis as a tool for identifying new modulators of mitosis.Catalytic enantioselective synthesis of functionalized tropanes reveals novel inhibitors of hedgehog signaling.A general catalytic reaction sequence to access alkaloid-inspired indole polycyclesCatalytic Aerobic Oxidation and Tandem Enantioselective Cycloaddition in Cascade Multicomponent SynthesisHighly Enantioselective Intramolecular 1,3-Dipolar Cycloaddition: A Route to Piperidino-Pyrrolizidines
P2860
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P2860
A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
A natural product inspired tet ...... ally target CSE1L and tubulin.
@en
A natural product inspired tet ...... ally target CSE1L and tubulin.
@nl
type
label
A natural product inspired tet ...... ally target CSE1L and tubulin.
@en
A natural product inspired tet ...... ally target CSE1L and tubulin.
@nl
prefLabel
A natural product inspired tet ...... ally target CSE1L and tubulin.
@en
A natural product inspired tet ...... ally target CSE1L and tubulin.
@nl
P2093
P2860
P356
P1476
A natural product inspired tet ...... ally target CSE1L and tubulin.
@en
P2093
Andreas Brockmeyer
Beate Schölermann
Claas Gerding-Reimers
Hugo Lachance
Petra Janning
Sabrina Bergmann
Slava Ziegler
Tobias Voigt
Tuyen Thi Ngoc Tran
P2860
P304
P356
10.1002/ANIE.201205728
P407
P577
2012-10-18T00:00:00Z