Inhibition of α-synuclein aggregation by small heat shock proteins.
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Targeting heat shock proteins to modulate α-synuclein toxicityHuman small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an updateHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateMolecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesThe Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins.Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta.Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.Pharmacoinformatic and molecular docking studies reveal potential novel antidepressants against neurodegenerative disorders by targeting HSPB8.Pathology-dependent effects linked to small heat shock proteins expression: an updateThe chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.Protein Quality Control by Molecular Chaperones in Neurodegeneration.Synaptic protein alterations in Parkinson's disease.Protein interactomes of three stress inducible small heat shock proteins: HspB1, HspB5 and HspB8.Potential synergy between tau aggregation inhibitors and tau chaperone modulators.Contribution of small heat shock proteins to muscle development and function.Barcoding heat shock proteins to human diseases: looking beyond the heat shock responseMolecular chaperones and neuronal proteostasis.The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases.ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.The growing world of small heat shock proteins: from structure to functions.Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.In vitro aggregation assays for the characterization of α-synuclein prion-like properties.Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of AggregationHow do thermophilic proteins resist aggregation?The minimal α-crystallin domain of Mj Hsp16.5 is functional at non-heat-shock conditions.Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.Heat Shock Proteins and Autophagy Pathways in Neuroprotection: from Molecular Bases to Pharmacological Interventions.The small heat shock proteins αB-crystallin (HSPB5) and Hsp27 (HSPB1) inhibit the intracellular aggregation of α-synuclein.Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.
P2860
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P2860
Inhibition of α-synuclein aggregation by small heat shock proteins.
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2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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2011年學術文章
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name
Inhibition of α-synuclein aggregation by small heat shock proteins.
@en
Inhibition of α-synuclein aggregation by small heat shock proteins.
@nl
type
label
Inhibition of α-synuclein aggregation by small heat shock proteins.
@en
Inhibition of α-synuclein aggregation by small heat shock proteins.
@nl
prefLabel
Inhibition of α-synuclein aggregation by small heat shock proteins.
@en
Inhibition of α-synuclein aggregation by small heat shock proteins.
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of α-synuclein aggregation by small heat shock proteins
@en
P2093
Alexandra A M Versleijen
Ilona B Bruinsma
Ine M J Segers-Nolten
Karsten Kinast
Kim A Bruggink
Marcel M Verbeek
Robert M W de Waal
Vinod Subramaniam
Wilbert Boelens
P2860
P304
P356
10.1002/PROT.23152
P407
P50
P577
2011-08-26T00:00:00Z