ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.
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Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cellsTumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cellsOncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cellsOvercoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expressionEGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo.Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancerMitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrestras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects.Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestineX-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer modelDeath receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer.Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines.Integration of autophagy and anoikis resistance in solid tumors.Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cellsAnoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists.Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation.cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein.Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.The opposing roles of cellular inhibitor of apoptosis proteins in cancer.Tumour-suppression function of KLF12 through regulation of anoikis.Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm.Mek activity is required for ErbB2 expression in breast cancer cells detached from the extracellular matrix.Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells.
P2860
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P2860
ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@en
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@nl
type
label
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@en
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@nl
prefLabel
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@en
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@nl
P2093
P2860
P356
P1476
ras Oncogene triggers up-regul ...... of ras-induced transformation.
@en
P2093
Eric C LaCasse
Hongbing Li
Jorge Filmus
Kirill V Rosen
Mathieu Derouet
Robert G Korneluk
Robert S Kerbel
Zaiping Liu
P2860
P304
37383-37392
P356
10.1074/JBC.M503724200
P407
P577
2005-08-22T00:00:00Z