Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
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Telomeres in Cancer TherapyTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationMammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophyComplex roles for telomeres and telomerase in breast carcinogenesisA balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytesTelomeres in aging and disease: lessons from zebrafishTelomere shortening in human diseasesIncreased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.Natural and pharmacological regulation of telomeraseA p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles.Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.Behaviour of telomere and telomerase during aging and regeneration in zebrafish.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Cell senescence and cancer.Constitutive telomerase expression promotes mammary carcinomas in aging mice.Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies.The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progressionBeyond average: potential for measurement of short telomeres.TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.Telomeres in cancer and ageing.Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer developmentAblation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation.Telomerase and cancer: time to move from a promising target to a clinical reality.Telomeres, aging and cancer: in search of a happy ending.Many ways to telomere dysfunction: in vivo studies using mouse models.Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.Short telomeres limit tumor progression in vivo by inducing senescence.Regulation of senescence in cancer and aging.Increased p53 activity does not accelerate telomere-driven ageing.The longest telomeres: a general signature of adult stem cell compartments.Signaling through estrogen receptors modulates telomerase activity in human prostate cancer.Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4BGenetic analysis of myc and telomerase interactions in vivo.In vivo role of checkpoint kinase 2 in signaling telomere dysfunction.Telomere dysfunction promotes metastasis in a TERC null mouse model of head and neck cancer.Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.
P2860
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P2860
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@en
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@nl
type
label
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@en
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@nl
prefLabel
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@en
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@nl
P2093
P356
P1433
P1476
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
@en
P2093
González-Suárez E
P2888
P304
P356
10.1038/79089
P407
P577
2000-09-01T00:00:00Z
P5875
P6179
1034852384