rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
about
Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complexThe human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiationSpecific interaction between 14-3-3 isoforms and the human CDC25B phosphataseThe human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9Coordination of DNA damage responses via the Smc5/Smc6 complexDNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free systemHus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damageAnalysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingDisruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1The Schizosaccharomyces pombe rad3 checkpoint geneChk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointS-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombeThe human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sitesChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53Activation of the DNA damage checkpoint in mutants defective in DNA replication initiationEnhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS responseGerminating fission yeast spores delay in G1 in response to UV irradiationFission yeast Rad26 responds to DNA damage independently of Rad3Replication Stress: A Lifetime of Epigenetic ChangeStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairSeparate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.The SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage responseRecovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomasRetention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damageMammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathwayReconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexRegulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complexViral infections and cell cycle G2/M regulationCleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathwayRoles of Chk1 in cell biology and cancer therapyBlocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanismThe Schizosaccharomyces pombe checkpoint kinases Chk1 and Cds1 are important for cell survival in response to cisplatinPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointAberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) miceThe oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cellsSuppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast
P2860
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P2860
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@en
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@nl
type
label
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@en
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@nl
prefLabel
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@en
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@nl
P1433
P1476
rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
@en
P2093
N C Walworth
R Bernards
P304
P356
10.1126/SCIENCE.271.5247.353
P407
P577
1996-01-01T00:00:00Z