Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.
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Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium.Correlation between thyroid hormone status and hepatic hyperplasia and hypertrophy caused by the peroxisome proliferator-activated receptor alpha agonist Wy-14,643Mutagenicity of the peroxisome proliferators clofibrate, Wyeth 14,643 and di-2-ethylhexyl phthalate in the lacZ plasmid-based transgenic mouse mutation assayIs peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalatePromoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamineA reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism.Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogensImplications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.Role of chemically induced cell proliferation in carcinogenesis and its use in health risk assessmentSite-specific cell proliferation in renal tubular cells by the renal tubular carcinogen tris(2,3-dibromopropyl)phosphateConcepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis.Cell proliferation in the liver and thyroid of C57Bl/10J mice after dietary administration of chlordane.Relationship between the time of sustained ethyl acrylate forestomach hyperplasia and carcinogenicityCompensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis.An overview of peroxisome proliferator-induced hepatocarcinogenesis.Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for Kupffer cells?Peroxisome proliferator-activated receptors and cancer: challenges and opportunitiesSustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis.Changes in expression of cellular oncogenes and endogenous retrovirus-like sequences during hepatocarcinogenesis induced by a peroxisome proliferatorJuxtaposition of peroxisomes and chromosomes in mitotic hepatocytes following methyl clofenapate administration to rats.Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expressionConflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.DETERMINING DISEASE CAUSALITY FROM EXPERIMENTAL TOXICOLOGY STUDIES.PPARalpha- and DEHP-Induced CancersMechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liverMechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.Liver fatty acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators.A metabolomics investigation of non-genotoxic carcinogenicity in the rat.Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene.Measurement of ploidy and cell proliferation in the rodent liver.Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.Comparison of the hepatic effects of nafenopin and WY-14,643 on peroxisome proliferation and cell replication in the rat and Syrian hamster.
P2860
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P2860
Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh-hant
name
Relationship of hepatic peroxi ...... etic acid (Wy-14,643) in rats.
@en
Relationship of hepatic peroxi ...... etic acid (Wy-14,643) in rats.
@nl
type
label
Relationship of hepatic peroxi ...... etic acid (Wy-14,643) in rats.
@en
Relationship of hepatic peroxi ...... etic acid (Wy-14,643) in rats.
@nl
prefLabel
Relationship of hepatic peroxi ...... etic acid (Wy-14,643) in rats.
@en
Relationship of hepatic peroxi ...... etic acid (Wy-14,643) in rats.
@nl
P2093
P1433
P1476
Relationship of hepatic peroxi ...... cetic acid (Wy-14,643) in rats
@en
P2093
P304
P407
P577
1988-12-01T00:00:00Z