Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. - Wikidata - awgldk - TriplyDB

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

http://www.wikidata.org/entity/Q53609401

about

Cellular Mechanisms of Ciliary Length Control Ubiquitin-Mediated Degradation of Aurora Kinases The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer.C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility Cullins and cancer.The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells MYC and Breast Cancer.Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation.Evaluating the prognostic significance of FBXW7 expression level in human breast cancer by a meta-analysis of transcriptional profiles.Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7 Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.The importance of regulatory ubiquitination in cancer and metastasis.Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53 Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival.The stability of Fbw7α in M-phase requires its phosphorylation by PKC.FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients.Decreased expression of FBXW7 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.MiR-27a-3p promotes esophageal cancer cell proliferation via F-box and WD repeat domain-containing 7 (FBXW7) suppression.p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy.FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study.Reduced FBXW7 expression in pancreatic cancer correlates with poor prognosis and chemotherapeutic resistance via accumulation of MCL1.Promotional effect of microRNA-194 on breast cancer cells via targeting F-box/WD repeat-containing protein 7.Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.FBXW7: a critical tumor suppressor of human cancers

P2860

Q26769756-18A7E0C2-F1DC-45E8-A99D-762C5CE5F602 Q26770280-E5023B8F-B14D-4340-800A-E5D8FD9D4F21 Q28249259-9E30469B-5BF7-476E-9F8F-C56BE11222E1 Q30781182-CFBFC545-CBC4-4E60-AEAA-3264C84127C7 Q33690321-DE2B3BEB-1400-486C-93DE-2848EF4ED722 Q33927425-7A3FBE7D-6811-4411-A7E7-319B55355CED Q34163470-9FDADED2-990E-4230-AC38-D3A062ECC22F Q34365216-5B00E8E6-E29C-41A2-884E-11E556FBF130 Q34479984-36EE422E-DC86-48AE-AD58-0D9B61F2D968 Q34619655-B07E8955-2DF2-4C12-BCED-1F5020AACC06 Q34972381-9FE0B613-50BA-4B52-8759-8CA259BF1C96 Q35692037-33C2D1A9-927D-4570-8553-642607302931 Q35859974-B8E4F703-68EF-4830-AA88-74A39BC1D20A Q36071656-75390A22-7374-4CFF-A5BE-3098B56A06AA Q36184728-769EA740-34F9-4151-B8FA-C6FD52722DBC Q36304176-674AA496-8015-4DF5-86C8-7FBCBFD36DC0 Q36344621-7B21D946-5A90-46B0-814B-134D9B1D4F85 Q36739319-AA40282D-A947-4349-9092-316E63992BB2 Q37314768-D74A15FE-2CD2-48D6-B462-CD37EFC4387E Q37375225-770A66BB-5EE9-426F-AB52-E3F173958C2E Q37607744-C1D58F3B-C9DB-45F1-A422-E6F8A2FC384A Q37802059-F982646F-5B05-45BE-A457-75D20BF3DFAC Q38854407-5D55D376-21D9-4A14-8E53-BD139C893040 Q39122602-269C359E-23A9-4586-94F5-3914955F0233 Q39430447-F8A618A8-98C2-463C-BDEA-E88646B63914 Q41407670-64C973B3-BCF3-4BA5-81A5-56901E67E24A Q41545354-C2B9ABF5-1E62-48EC-90FB-97F22095DC89 Q41822859-06043E05-2BA5-455A-A74B-0CA8B475E83A Q42205041-0380EA65-3154-4C79-891B-127681EA2799 Q42779463-501FAE2C-B70D-4CC9-A8D5-54ED8AEC8B2B Q43197266-8C0BF649-F323-4C55-825C-4FA31620A6C0 Q46661944-F85BD5F0-1C08-4E4F-9853-C4CDDBF1284F Q47601708-82293783-1545-4AFD-99A7-6B0CF38923EB Q49246389-4569C60F-3CF5-4C04-B83F-B2D5E4E25495 Q52655150-5FDCC251-0F2A-4D5F-A632-4FC1C099DB8D Q54394270-D4396872-D2A6-4DFE-AA41-B82CFEF4C317 Q58797685-78DA0400-4FD1-48F9-86BE-6B980D7ADFF5

P2860

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

http://www.wikidata.org/entity/Q53609401

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年学术文章

@wuu

2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

2006年學術文章

@zh

2006年學術文章

@zh-hant

name

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@en

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@nl

type

label

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@en

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@nl

prefLabel

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@en

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@nl

P1433

Q53609401-6595E07E-2799-46B9-BD58-616BD906B399

P1476

Q53609401-3E10AA6A-42FC-435A-ACB6-156FEA572C44

P2093

Q53609401-0B4C6745-9790-4BFE-83B2-167F936CCAEE

Q53609401-2B564DAC-7E50-4BB5-9813-E120837249B7

Q53609401-2DC5ACAB-D256-47CA-A77B-F3A54B96AB4B

Q53609401-3DE6904B-B668-4E00-8961-1AB4D7733740

Q53609401-4EE2043A-4AD4-40BD-A79C-7E3435ED487C

Q53609401-53D4B274-13E4-4B92-9C52-403466095680

Q53609401-7217AEF0-E4A4-4B39-A0AF-5542F1EBE6F0

Q53609401-9581D971-3698-41AB-8296-0BA955415A9A

Q53609401-A059146D-CD25-422F-B28E-C4FEC52D8348

P2860

Q53609401-01D56B96-C414-4163-AD9A-B72E105B6125

Q53609401-0789EFF6-B371-405E-8424-BBDC15ACD65F

Q53609401-0F4966B5-D92F-4D42-ADA4-BCF93F32B5C1

Q53609401-0F92D835-8A0D-4136-9D7E-F004294C06FD

Q53609401-13336301-C33A-481F-9969-A5FA06DBA6E2

Q53609401-14FE88A5-1487-457C-9F25-686CC97B28D7

Q53609401-16E347DB-A577-457E-A93C-401D5DD6B1D1

Q53609401-1CA09F9D-4714-43C9-B4CC-A88E0281FD20

Q53609401-1CCA8B10-1CA8-4014-AA0C-1C48C98E169A

Q53609401-386C2CEC-4DFC-4B74-B49D-92CEF63CBE7F

P304

Q53609401-A53C5809-BF31-4FDA-A230-AC80E9FCD835

P31

Q53609401-41F2DF79-2338-44ED-8A19-2BFDFC101BC2

P356

Q53609401-37EC24EB-E5BA-4882-87F6-2D2D09932C4C

P433

Q53609401-2FED979D-6701-4A28-B5AB-A20DEDD5D3B6

P478

Q53609401-9158626B-736C-435A-87DE-6EB8CBB2570B

P50

Q53609401-CB8532B6-D4C6-4580-88DC-9422605D525A

P577

Q53609401-7EFB39D7-C1EE-489F-ACAE-1C758DE6128C

P5875

Q53609401-39B34F4B-6CC7-4006-B421-F7CFBE3CA926

P698

Q53609401-944B883C-6826-47AC-B146-FF8B971D5A54

P356

J.1349-7006.2006.00239.X

P1433

P1476

Fbxw7 contributes to tumor sup ...... iquitin-dependent degradation.

@en

P2093

Akinobu Matsumoto

http://www.w3.org/2001/XMLSchema#string

Hidehisa Takahashi

http://www.w3.org/2001/XMLSchema#string

Keiichi I Nakayama

http://www.w3.org/2001/XMLSchema#string

Masaaki Nishiyama

http://www.w3.org/2001/XMLSchema#string

Masayoshi Yada

http://www.w3.org/2001/XMLSchema#string

Ryosuke Tsunematsu

http://www.w3.org/2001/XMLSchema#string

Tadashi Nakagawa

http://www.w3.org/2001/XMLSchema#string

Takumi Kamura

http://www.w3.org/2001/XMLSchema#string

Yo Fujii

http://www.w3.org/2001/XMLSchema#string

P2860

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

The ubiquitin system

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

P304

729-736

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1111/J.1349-7006.2006.00239.X

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

97

http://www.w3.org/2001/XMLSchema#string

P50

P577

2006-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6921673

http://www.w3.org/2001/XMLSchema#string

P698

16863506

http://www.w3.org/2001/XMLSchema#string