BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. - Wikidata - awgldk - TriplyDB

BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

http://www.wikidata.org/entity/Q53633362

about

Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation Daxx is reciprocally regulated by Mdm2 and Hausp Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer The genomic complexity of primary human prostate cancer The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression Prolyl isomerase Pin1 in cancer Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation.Transcription of the rat testis-specific Rtdpoz-T1 and -T2 retrogenes during embryo development: co-transcription and frequent exonisation of transposable element sequences.A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila.POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data Nac1 interacts with the POZ-domain transcription factor, Miz1.Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development.SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1.Cullins and cancer.The emerging role of speckle-type POZ protein (SPOP) in cancer development.Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.Adenovirus precursor pVII protein stability is regulated by its propeptide sequence.Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants.Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.The genomic basis of parasitism in the Strongyloides clade of nematodes Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation.SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells.Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.

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P2860

BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

http://www.wikidata.org/entity/Q53633362

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年学术文章

@wuu

2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

2006年學術文章

@zh

2006年學術文章

@zh-hant

name

BTB domain-containing speckle- ...... y Cul3-based ubiquitin ligase.

@en

BTB domain-containing speckle-type POZ protein

@nl

type

label

BTB domain-containing speckle- ...... y Cul3-based ubiquitin ligase.

@en

BTB domain-containing speckle-type POZ protein

@nl

prefLabel

BTB domain-containing speckle- ...... y Cul3-based ubiquitin ligase.

@en

BTB domain-containing speckle-type POZ protein

@nl

P1433

Q53633362-1C3E62D6-732E-4710-81D4-8D3B159FA494

P1476

Q53633362-65C19F43-A5DF-46E9-98B4-D88E97BF77F2

P2093

Q53633362-1F92685C-3653-4A44-8AC2-61120B53A257

Q53633362-208B630E-DAA4-4861-B63D-EE5BD70D0D79

Q53633362-230B88CA-23DE-4692-B96E-DA6A40861093

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Q53633362-A687DD0B-62D3-4D62-A55F-B5BF547676A0

Q53633362-B7F3197B-1BE5-41E5-AF5F-3914048CDA6A

P2860

Q53633362-0036B912-C409-4705-82E5-28A83DD9CEE7

Q53633362-03AFDE92-0C3C-4575-9E00-B62B7B039498

Q53633362-1DD06C1C-9CAA-4E59-8BF2-84D72DA5FE41

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Q53633362-31C0A3F9-E5F9-4095-885D-D0F7C0625F57

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P304

Q53633362-A33CB7A5-E159-4D43-B6F7-4D577497FBF1

P31

Q53633362-D9741DDC-2161-4B08-AFCA-036A8D5693A0

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P407

Q53633362-25AD435B-2BF8-4A09-861A-B2A7A00E0E8A

P433

Q53633362-5E6899D6-4093-4DB9-B508-BF1607F79BD4

P478

Q53633362-F7D61929-B322-4AF6-9AD4-1D0385DA777A

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Q53633362-6A8FBD60-1B3F-42F0-839F-DBCDB45B6E19

P698

Q53633362-CDBC9577-82EE-4DD9-AE42-BBF83248C4D7

P921

Q53633362-5BD7519D-D14C-4AE5-861C-E8369C8208F2

P356

P1433

Journal of Biological Chemistry

P1476

BTB domain-containing speckle- ...... y Cul3-based ubiquitin ligase.

@en

P2093

Cheol O Joe

http://www.w3.org/2001/XMLSchema#string

Chin Ha Chung

http://www.w3.org/2001/XMLSchema#string

Gi Ryang Kim

http://www.w3.org/2001/XMLSchema#string

Jae Hong Seol

http://www.w3.org/2001/XMLSchema#string

Jeong Eun Kwon

http://www.w3.org/2001/XMLSchema#string

Keiji Tanaka

http://www.w3.org/2001/XMLSchema#string

Kyu Hee Oh

http://www.w3.org/2001/XMLSchema#string

Muhnho La

http://www.w3.org/2001/XMLSchema#string

Ok Sun Bang

http://www.w3.org/2001/XMLSchema#string

Sung Hee Baek

http://www.w3.org/2001/XMLSchema#string

P2860

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes

PUMA, a novel proapoptotic gene, is induced by p53

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

Daxx silencing sensitizes cells to multiple apoptotic pathways

Negative regulation of p53 functions by Daxx and the involvement of MDM2

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

P304

12664-12672

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M600204200

http://www.w3.org/2001/XMLSchema#string

P407

P433

18

http://www.w3.org/2001/XMLSchema#string

P478

281

http://www.w3.org/2001/XMLSchema#string

P577

2006-03-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16524876

http://www.w3.org/2001/XMLSchema#string

P921

protein ubiquitination