about
sameAs
Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurFPreclinical evaluation of novel antibacterial agents by microbiological and molecular techniques6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligaseElucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosaTransposon library screening for identification of genetic loci participating in intrinsic susceptibility and acquired resistance to antistaphylococcal agents.Increased mutability of Staphylococci in biofilms as a consequence of oxidative stressExploiting current understanding of antibiotic action for discovery of new drugs.Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence.Distribution of fusidic acid resistance determinants in methicillin-resistant Staphylococcus aureus.Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).Zeocin resistance suppresses mutation in hypermutable Escherichia coli.Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms.In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.Targeting bacterial membrane function: an underexploited mechanism for treating persistent infectionsABC-F Proteins Mediate Antibiotic Resistance through Ribosomal ProtectionStructure-based ligand design of novel bacterial RNA polymerase inhibitors.A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.Impact of exposure of methicillin-resistant Staphylococcus aureus to polyhexanide in vitro and in vivo.Loss of function of the gdpP protein leads to joint β-lactam/glycopeptide tolerance in Staphylococcus aureus.Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent.Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme.A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureusRedox-active compounds with a history of human use: antistaphylococcal action and potential for repurposing as topical antibiofilm agentsGenetic basis of resistance to fusidic acid in staphylococci.In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistanceThe target of daptomycin is absent from Escherichia coli and other gram-negative pathogens.Characterization of the epidemic European fusidic acid-resistant impetigo clone of Staphylococcus aureus.Mutagenesis mapping of the protein-protein interaction underlying FusB-type fusidic acid resistance."tet(U)" is not a tetracycline resistance determinant.Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymeraseFurther characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studiesUse of mutator strains for characterization of novel antimicrobial agentsA target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus.Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.Anti-staphylococcal activity and mode of action of clofazimine.Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.
P50
Q27684854-4E494569-CE28-40A6-BD03-E00D512F8D5DQ28273315-9D87095C-A153-478B-BBA8-08CDF181DA9BQ28481777-F77FF34F-C410-4992-BA09-9154280EDCDBQ28551971-7D44D608-2866-4BD3-A0A0-EFAF56D4A884Q34436348-10BA5C1E-CD8C-4888-8436-03DFBC6194AFQ34460524-524EED8E-65E0-4C63-85C7-E412BE7FD800Q34631418-0BCC6DF6-A652-4352-92C4-72981C8653E2Q34706784-F5B7EB1E-C901-423C-B5DC-C354E8950CCCQ34737419-481AE68C-A6DF-4AA1-AD02-FFA8A6C05AB6Q34836178-3F5829F3-B637-448C-8673-D69B31E3CDF1Q35103697-F556C39E-2845-48B1-A4BA-F38A2B61D47AQ35167197-FEC9B255-633D-46CB-A4EE-41159AB59E56Q35870415-62DA7F38-6EDE-44D9-A079-A6DA996B6DD4Q36393640-5EEC1534-4894-4994-BBE0-3D26531E2313Q39486737-A44E84C3-F96A-4795-81E2-2623BFA86170Q39507682-C6F7C3AA-0725-4406-8E19-23DF47672F0CQ39955761-EDFD8876-9ADC-4A13-8E33-9E8AC938BB88Q40103251-D0B1ADDF-2386-42EA-8EEA-3C6DFC0B6737Q40327518-4EA801CA-B498-4B9F-A678-5284F187B87CQ40696433-B53DE07D-7920-49A7-AFDA-562330300DD5Q41194288-0FFD202C-91E3-45D4-8435-796649FF865FQ41291826-281FEA4F-CC15-4374-B5B6-58840DB35D55Q41678275-026C3753-A58E-416E-BDD4-E65E5BC410C6Q41809069-76EBE759-042E-4EC4-9C9D-1DBADAAA7E7DQ41885921-0795BBF6-3486-4012-9B7E-1AABC6813E55Q41978763-0C98BF0D-4C31-4F0C-8258-2242F41EA0BDQ41991408-295A3106-0629-4A3E-9437-666C6FCCFE05Q42070250-0E466246-1AA7-4645-B17F-F2040295CA54Q42190076-E4A3ECC6-F3DD-42AE-8426-66F2092A0177Q42242488-9C5B3317-BBD2-48C9-BAAC-26EC6720C03BQ42421156-D6A745E0-0086-4B45-8526-E3C26F879EEDQ42706360-76E7E947-A91E-4934-BCFA-2651DF46E553Q42730426-123E476D-10D4-4A39-B3D3-ACCDE4A8D7C9Q43069439-762E6456-EC4B-4AF1-964D-51CADF2038EFQ43592286-630C99B9-1CBC-46A1-BD7E-D64F61725603Q44012036-2AF19463-ADEB-4575-B818-7799DE8E35C6Q44681057-FD3C719A-5CA2-4952-9393-94F92336C4EDQ44755229-705B18D3-AA75-4460-8875-CF9754DC192AQ46041950-BC25689B-B54A-4446-98A2-B5465BD2FD09Q46052197-4FC1E86D-61AD-4B86-89B8-A5929F2210F1
P50
description
hulumtues
@sq
researcher
@en
researcher
@en-gb
wetenschapper
@nl
հետազոտող
@hy
name
Alex John O'Neill
@ast
Alex John O'Neill
@br
Alex John O'Neill
@ca
Alex John O'Neill
@cs
Alex John O'Neill
@cy
Alex John O'Neill
@da
Alex John O'Neill
@de
Alex John O'Neill
@de-at
Alex John O'Neill
@de-ch
Alex John O'Neill
@en
type
label
Alex John O'Neill
@ast
Alex John O'Neill
@br
Alex John O'Neill
@ca
Alex John O'Neill
@cs
Alex John O'Neill
@cy
Alex John O'Neill
@da
Alex John O'Neill
@de
Alex John O'Neill
@de-at
Alex John O'Neill
@de-ch
Alex John O'Neill
@en
altLabel
Alex J O'Neill
@en
Alex O'Neill
@br
Alex O'Neill
@ca
Alex O'Neill
@cs
Alex O'Neill
@cy
Alex O'Neill
@da
Alex O'Neill
@de
Alex O'Neill
@de-at
Alex O'Neill
@de-ch
Alex O'Neill
@en
prefLabel
Alex John O'Neill
@ast
Alex John O'Neill
@br
Alex John O'Neill
@ca
Alex John O'Neill
@cs
Alex John O'Neill
@cy
Alex John O'Neill
@da
Alex John O'Neill
@de
Alex John O'Neill
@de-at
Alex John O'Neill
@de-ch
Alex John O'Neill
@en
P1416
P6366
P106
P1153
7101821796
P1416
P2031
2000-01-01T00:00:00Z
P21
P31
P496
0000-0003-3222-5493
P6178
012531117457.04
P6366
2131866698