Directed evolution of a stable scaffold for T-cell receptor engineering.
about
The HAC1 gene from Pichia pastoris: characterization and effect of its overexpression on the production of secreted, surface displayed and membrane proteinsIdentification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesotheliomaMimotopes for alloreactive and conventional T cells in a peptide-MHC display libraryEngineered IgG1-Fc--one fragment to bind them allApplications of Yeast Surface Display for Protein EngineeringGlioblastoma cancer stem cells: Biomarker and therapeutic advancesDevelopment of a humanized monoclonal antibody with therapeutic potential against West Nile virusCrystal structure of a complete ternary complex of TCR, superantigen and peptide-MHCDistinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientationDifferent Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeastRecombinant antibodies for cancer diagnosis and therapy.Screening for stable mutants with amino acid pairs substituted for the disulfide bond between residues 14 and 38 of bovine pancreatic trypsin inhibitor (BPTI).Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library.Predicting oligonucleotide-directed mutagenesis failures in protein engineering.Fluorescence-activated cell sorting of specific affibody-displaying staphylococci.Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions.Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld.A decade of yeast surface display technology: where are we now?Engineering higher affinity T cell receptors using a T cell display system.Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniproteinT cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies.Stability engineering of scFvs for the development of bispecific and multivalent antibodies.Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins.Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.Toward development of a screen to identify randomly encoded, foldable sequences.T cell avidity and tumor immunity: problems and solutionsDirected evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeastDirected evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae.Optimizing recombinant antibodies for intracellular function using hitchhiker-mediated survival selectionConstruction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and functionDirected evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display.Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display.Rapid optimization and prototyping for therapeutic antibody-like molecules.Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.Long-range cooperative binding effects in a T cell receptor variable domain.Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc.
P2860
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P2860
Directed evolution of a stable scaffold for T-cell receptor engineering.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Directed evolution of a stable scaffold for T-cell receptor engineering.
@en
Directed evolution of a stable scaffold for T-cell receptor engineering.
@nl
type
label
Directed evolution of a stable scaffold for T-cell receptor engineering.
@en
Directed evolution of a stable scaffold for T-cell receptor engineering.
@nl
prefLabel
Directed evolution of a stable scaffold for T-cell receptor engineering.
@en
Directed evolution of a stable scaffold for T-cell receptor engineering.
@nl
P2093
P2860
P356
P1433
P1476
Directed evolution of a stable scaffold for T-cell receptor engineering.
@en
P2093
P2860
P2888
P304
P356
10.1038/77325
P577
2000-07-01T00:00:00Z