Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.
about
Targeting and transport: how microtubules control focal adhesion dynamicsRho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamicsSLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarizationCentral role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assemblyThe RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cellsHomozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defensesProteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen.Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway.Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder.Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALINGChanges in the GEF-H1 pathways after traumatic brain injury.Post-polymerization crosstalk between the actin cytoskeleton and microtubule network.GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.Guanine nucleotide exchange factor -H1 promotes inflammatory cytokine production and intracellular mycobacterial elimination in macrophages.Differential role for PAK1 and PAK4 during the invadopodia lifecycle.Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.Technical advance: Inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments.DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor.Beet yellows virus replicase and replicative compartments: parallels with other RNA viruses.Dynamic microtubules regulate cellular contractility during T-cell activation.Different modes of APC/C activation control growth and neuron-glia interaction in the developing Drosophila eye.Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.Myosin II-interacting guanine nucleotide exchange factor (MYOGEF) promotes bleb retraction via stimulating cortex reassembly at the bleb membrane.Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils.Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling
P2860
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P2860
Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@en
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@nl
type
label
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@en
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@nl
prefLabel
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@en
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@nl
P2093
P1433
P1476
Mechanistic insight into the m ...... n-dependent RhoGEF inhibition.
@en
P2093
Chris Bakal
Chuanjin Wu
David Meiri
Fernando Suarez
Jose Larose
Marc Balan
Melissa A Greeve
Mitsuhiko Ikura
P304
P356
10.1016/J.MOLCEL.2012.01.027
P577
2012-03-01T00:00:00Z