Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
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Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of DiseasesRegulation of with-no-lysine kinase signaling by Kelch-like proteins.Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced Hypertension.The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2).Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.Negative News: Cl- and HCO3- in the Vascular Wall.WNK Kinases in Development and Disease.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse.Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon.Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study.Distal convoluted tubule.Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney
P2860
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P2860
Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Effect of heterozygous deletio ...... the kidney and blood vessels.
@en
Effect of heterozygous deletio ...... the kidney and blood vessels.
@nl
type
label
Effect of heterozygous deletio ...... the kidney and blood vessels.
@en
Effect of heterozygous deletio ...... the kidney and blood vessels.
@nl
prefLabel
Effect of heterozygous deletio ...... the kidney and blood vessels.
@en
Effect of heterozygous deletio ...... the kidney and blood vessels.
@nl
P2093
P2860
P1476
Effect of heterozygous deletio ...... the kidney and blood vessels.
@en
P2093
Akihito Ohta
Eisei Sohara
Koichiro Susa
Satomi Kita
Sei Sasaki
Shih-Hua Lin
Shinichi Uchida
Sung-Sen Yang
Takahiro Iwamoto
Tatemitsu Rai
P2860
P2888
P304
P356
10.1007/S10157-012-0590-X
P577
2012-08-01T00:00:00Z