HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
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PKCδ stabilizes TAp63 to promote cell apoptosisHomeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the EpigenomeThe Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemTP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Regulation of p63 protein stability via ubiquitin-proteasome pathway.Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradationPhosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.Pathway Regulation of p63, a Director of Epithelial Cell FateHIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicityUpdates on HIPK2: a resourceful oncosuppressor for clearing cancerRole of p63 in Development, Tumorigenesis and Cancer ProgressionHIPK family kinases bind and regulate the function of the CCR4-NOT complex.Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.Hyperglycemia triggers HIPK2 protein degradation.HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control.How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.A hidden role of the inactivated FANCD2: upregulating ΔNp63.New Insights in Thyroid Cancer and p53 Family Proteins.HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells.Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.
P2860
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P2860
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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2011年學術文章
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2011年學術文章
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name
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
@en
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
@nl
type
label
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
@en
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
@nl
prefLabel
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
@en
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
@nl
P2093
P2860
P50
P356
P1433
P1476
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage
@en
P2093
A Prodosmo
L Guerrini
M Gentileschi
P2860
P2888
P304
P356
10.1038/ONC.2011.182
P407
P577
2011-05-23T00:00:00Z