about
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayHIPK2: a multitalented partner for transcription factors in DNA damage response and development.HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradationHigh-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicityTherapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia.HIPKs: Jack of all trades in basic nuclear activities.MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities.CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to CytokinesisExtrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Cinzia Rinaldo
@ast
Cinzia Rinaldo
@en
Cinzia Rinaldo
@es
Cinzia Rinaldo
@nl
type
label
Cinzia Rinaldo
@ast
Cinzia Rinaldo
@en
Cinzia Rinaldo
@es
Cinzia Rinaldo
@nl
prefLabel
Cinzia Rinaldo
@ast
Cinzia Rinaldo
@en
Cinzia Rinaldo
@es
Cinzia Rinaldo
@nl
P106
P1153
7103380061
P31
P496
0000-0001-6124-762X