Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. - Wikidata - awgldk - TriplyDB

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

http://www.wikidata.org/entity/Q54588340

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Domain specific interaction in the XRCC1-DNA polymerase beta complex DNA polymerase family X: function, structure, and cellular roles A variant of DNA polymerase beta acts as a dominant negative mutant Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation The Family X DNA Polymerase from Deinococcus radiodurans Adopts a Non-standard Extended Conformation DNA Polymerase Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"Structure of Escherichia coli AlkA in Complex with Undamaged DNA Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase β Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines Structure and mechanism of DNA polymerase β A quantitative model of human DNA base excision repair. I. Mechanistic insights.Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 Computational delineation of tyrosyl-substrate recognition and catalytic landscapes by the epidermal growth factor receptor tyrosine kinase domain.Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change.Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival Chance favors the prepared genome.DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding.Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.Minor Groove Interactions between Polymerase and DNA: More Essential to Replication than Watson-Crick Hydrogen Bonds?Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes.Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.In silico evidence for DNA polymerase-beta's substrate-induced conformational change Identification of critical residues for the tight binding of both correct and incorrect nucleotides to human DNA polymerase λ The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β Modeling DNA polymerase μ motions: subtle transitions before chemistry.Substrate-induced DNA polymerase β activation.Interaction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites.Unnatural substrate repertoire of A, B, and X family DNA polymerases.Energy analysis of chemistry for correct insertion by DNA polymerase beta.Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda.Streisinger revisited: DNA synthesis errors mediated by substrate misalignments.DNA polymerase beta and mammalian base excision repair.3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.

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P2860

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

http://www.wikidata.org/entity/Q54588340

description

1996 nî lūn-bûn

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1996年學術文章

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Enzyme-DNA interactions requir ...... in human DNA polymerase beta.

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Beard WA

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Jaju M

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Kraut J

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Kunkel TA

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Wood TG

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P2860

Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing

Polymerase structures and function: variations on a theme?

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

Rapid and efficient site-specific mutagenesis without phenotypic selection

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents.

Sequence-specific recognition of double helical nucleic acids by proteins.

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