Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.
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Three decades of beta-lactamase inhibitorsThe crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibioticsSaturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinaseSelection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase geneCharacterization of a chromosomal gene encoding type B beta-lactamase in phage group II isolates of Staphylococcus aureus.Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases.Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytocaTLA-1: a new plasmid-mediated extended-spectrum beta-lactamase from Escherichia coli.Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamaseExtended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.Chromosomal beta-lactamase genes of Klebsiella oxytoca are divided into two main groups, blaOXY-1 and blaOXY-2.Variability of chromosomally encoded beta-lactamases from Klebsiella oxytoca.Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faeciumStructure-function relationships among wild-type variants of Staphylococcus aureus beta-lactamase: importance of amino acids 128 and 216.Hydrolysis spectrum extension of CMY-2-like β-lactamases resulting from structural alteration in the Y-X-N loop.Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases.Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases.Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species.Active-site serine mutants of the Streptomyces albus G beta-lactamase.Inhibitor-resistant OXY-2-derived beta-lactamase produced by Klebsiella oxytoca.Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant.Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator.The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations.Catalytic properties of class A beta-lactamases: efficiency and diversity.Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.Effect of side-chain amide thionation on turnover of beta-lactam substrates by beta-lactamases. Further evidence on the question of side-chain hydrogen-bonding in catalysis.The mechanism of action of DD-peptidases: the role of tyrosine-159 in the Streptomyces R61 DD-peptidase.The mutation Lys234His yields a class A beta-lactamase with a novel pH-dependenceMechanism of acyl transfer by the class A serine beta-lactamase of Streptomyces albus G.Point mutations of two arginine residues in the Streptomyces R61 DD-peptidase.Importance of the two tryptophan residues in the Streptomyces R61 exocellular DD-peptidase.Streptomyces albus G serine beta-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes.Mechanism of action of DD-peptidases: role of asparagine-161 in the Streptomyces R61 DD-peptidase.Site-directed mutagenesis of proposed active-site residues of penicillin-binding protein 5 from Escherichia coliThe importance of the negative charge of beta-lactam compounds in the interactions with active-site serine DD-peptidases and beta-lactamases.pKa calculations for class A beta-lactamases: methodological and mechanistic implications.
P2860
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P2860
Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
Role of the conserved amino ac ...... by site-directed mutagenesis.
@en
type
label
Role of the conserved amino ac ...... by site-directed mutagenesis.
@en
prefLabel
Role of the conserved amino ac ...... by site-directed mutagenesis.
@en
P2093
P2860
P356
P1433
P1476
Role of the conserved amino ac ...... by site-directed mutagenesis.
@en
P2093
P2860
P304
P356
10.1042/BJ2710399
P407
P577
1990-10-01T00:00:00Z