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Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor DesignStructural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMPThe auto-inhibitory role of the EPAC hinge helix as mapped by NMRExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsElectrostatic Switch Function in the Mechanism of Protein Kinase A Iα Activation: Results of the Molecular Dynamics Simulation.Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitorsDynamically driven ligand selectivity in cyclic nucleotide binding domains.Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases.Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosisEPAC proteins transduce diverse cellular actions of cAMP.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition.Kinetics of ligand-receptor interaction reveals an induced-fit mode of binding in a cyclic nucleotide-activated proteinCharacterization of a cyclic nucleotide-activated K(+) channel and its lipid environment by using solid-state NMR spectroscopy.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Role of arginine 209 in the conformational transition of the protein kinase A regulatory subunit RIα A-domain.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Structural dynamics in the activation of Epac.
@en
Structural dynamics in the activation of Epac.
@nl
type
label
Structural dynamics in the activation of Epac.
@en
Structural dynamics in the activation of Epac.
@nl
prefLabel
Structural dynamics in the activation of Epac.
@en
Structural dynamics in the activation of Epac.
@nl
P2093
P2860
P356
P1476
Structural dynamics in the activation of Epac.
@en
P2093
Holger Rehmann
Johannes L Bos
Rainer W Wechselberger
Shannon M Harper
P2860
P304
P356
10.1074/JBC.M707849200
P407
P577
2007-12-31T00:00:00Z