Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.
about
Epigenetics and its implications for plant biology 2. The 'epigenetic epiphany': epigenetics, evolution and beyondInfluence of Friedreich ataxia GAA noncoding repeat expansions on pre-mRNA processingComparative genomics and molecular dynamics of DNA repeats in eukaryotesFriedreich ataxia: an overviewSurvey of human mitochondrial diseases using new genomic/proteomic toolsAdvances in mechanisms of genetic instability related to hereditary neurological diseases.Therapeutic developments in Friedreich ataxiaThe balancing act of DNA repeat expansionsExpanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cellsHDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse modelCrystal structure of human frataxinIdentification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiaeFriedreich ataxia: from GAA triplet-repeat expansion to frataxin deficiency.Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levelsPms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissuesDisruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA TargetingSpinocerebellar ataxia in the Italian Spinone dog is associated with an intronic GAA repeat expansion in ITPR1Structural heterogeneity of pyrimidine/purine-biased DNA sequence analyzed by atomic force microscopy.Tetraplex formation by the progressive myoclonus epilepsy type-1 repeat: implications for instability in the repeat expansion diseases.Progressive GAA.TTC repeat expansion in human cell lines.Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcriptionPGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia.Transposon Tn7 preferentially inserts into GAA*TTC triplet repeats under conditions conducive to Y*R*Y triplex formation.The GAA*TTC triplet repeat expanded in Friedreich's ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent mannerDevelopment of histone deacetylase inhibitors as therapeutics for neurological diseaseMutLα heterodimers modify the molecular phenotype of Friedreich ataxia.Alleviating transcript insufficiency caused by Friedreich's ataxia triplet repeatsAltered nucleosome positioning at the transcription start site and deficient transcriptional initiation in Friedreich ataxia.Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Intracellular iron transport and storage: from molecular mechanisms to health implications.A rapid, noninvasive immunoassay for frataxin: utility in assessment of Friedreich ataxiaMolecular basis of Friedreich ataxia.Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cellsSmall molecules affecting transcription in Friedreich ataxiaCis-elements governing trinucleotide repeat instability in Saccharomyces cerevisiae.Long homopurine*homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region.A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.Base excision repair of chemotherapeutically-induced alkylated DNA damage predominantly causes contractions of expanded GAA repeats associated with Friedreich's ataxia.On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.
P2860
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P2860
Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@en
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@nl
type
label
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@en
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@nl
prefLabel
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@en
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@nl
P2093
P1433
P1476
Sticky DNA: self-association p ...... ures from Friedreich's ataxia.
@en
P2093
Chastain PD
Griffith JD
Pandolfo M
Parniewski P
Sakamoto N
P304
P356
10.1016/S1097-2765(00)80474-8
P577
1999-04-01T00:00:00Z