Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.
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Crystal structure of human cytochrome P450 2D6Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutantsInfluence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agentFunctional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49)Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.Recent Structural Insights into Cytochrome P450 Function.Recurrent acute hepatitis associated with use of cetirizine.Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety.Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans.Re-engineering of CYP2C9 to probe acid-base substrate selectivityAn analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17).Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.Ile115Leu mutation in the SRS1 region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel.Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.Engineering of human CYP3A enzymes by combination of activating polymorphic variants.Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
P2860
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P2860
Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Evidence that aspartic acid 30 ...... e site of cytochrome P450 2D6.
@en
type
label
Evidence that aspartic acid 30 ...... e site of cytochrome P450 2D6.
@en
prefLabel
Evidence that aspartic acid 30 ...... e site of cytochrome P450 2D6.
@en
P2093
P2860
P356
P1476
Evidence that aspartic acid 30 ...... ve site of cytochrome P450 2D6
@en
P2093
A P Simula
G P Hayhurst
G T Tucker
M J Ackland
M J Sternberg
M S Lennard
T Lightfoot
P2860
P304
29055-29058
P356
10.1074/JBC.270.49.29055
P407
P577
1995-12-01T00:00:00Z