Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation
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Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cellsThe amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neuronsThe role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo.Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brainsDown-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neuronsIn situ assembly of enzyme inhibitors using extended tetheringMechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion proteinA whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CMultiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosisThe neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosisEffects of NK-4 in a transgenic mouse model of Alzheimer's diseaseMice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.Gene trap: a way to identify novel genes and unravel their biological function.Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells.Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation.Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures.Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.Suicidal tendencies: apoptotic cell death by caspase family proteinases.The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies.Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.Energy requirement for caspase activation and neuronal cell death.Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders.Neuroprotection by caspase inhibitors.The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?Apoptosis and its clinical impact.Structure and pathology of tau protein in Alzheimer disease.Apoptosis and dependence receptors: a molecular basis for cellular addiction.Alzheimer disease therapeutics.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.Altered processing of amyloid precursor protein in cells undergoing apoptosis.Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.Cell death mechanisms in neurodegeneration.Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.Death and survival of neuronal cells exposed to Alzheimer's insults.
P2860
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P2860
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation
description
article
@en
im April 1999 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 1999
@uk
ലേഖനം
@ml
name
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@en
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@nl
type
label
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@en
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@nl
prefLabel
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@en
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@nl
P2093
P1433
P1476
Involvement of Caspases in Pro ...... oidogenic Aβ Peptide Formation
@en
P2093
Andréa LeBlanc
David Smith
Donald W. Nicholson
Earl E. Clarke
François G. Gervais
George S. Robertson
JingQi Huang
John P. Vaillancourt
P304
P356
10.1016/S0092-8674(00)80748-5
P407
P577
1999-04-01T00:00:00Z