Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
about
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domainsPolycomb group genes: keeping stem cell activity in balancePolycomb group targeting through different binding partners of RING1B C-terminal domainRapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machineryRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexInteraction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cellsA long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophyEpigenetic control of embryonic stem cell fateRYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 geneThe quest for mammalian Polycomb response elements: are we there yet?A double take on bivalent promotersThe roles of retinoic acid and retinoic acid receptors in inducing epigenetic changesBivalent histone modifications in early embryogenesisHistone methylations in heart development, congenital and adult heart diseasesStructural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET DomainDeciphering the Epigenetic Code in Embryonic and Dental Pulp Stem CellsH2A.Z: a molecular rheostat for transcriptional controlOpposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactylyDistinct factors control histone variant H3.3 localization at specific genomic regionsERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cellsCpG islands and the regulation of transcriptionSwitches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination systemA novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1Reduction of Hox gene expression by histone H1 depletionPleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in DrosophilaTcf3 is an integral component of the core regulatory circuitry of embryonic stem cellsGenome-wide and cell-specific epigenetic analysis challenges the role of polycomb in Drosophila spermatogenesisNcoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogrammingOccupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutRegulating RNA polymerase pausing and transcription elongation in embryonic stem cellsThe Polycomb complex PRC2 and its mark in lifeStem cells, the molecular circuitry of pluripotency and nuclear reprogrammingControl of the embryonic stem cell stateDefining the chromatin signature of inducible genes in T cellsUbiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cellsThe Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTRMINIYO and transcriptional elongation: lifting the roadblock to differentiation.Molecular architecture of polycomb repressive complexesGenome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
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Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
description
article
@en
im November 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2007
@uk
name
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@en
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@nl
type
label
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@en
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@nl
prefLabel
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@en
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@nl
P2093
P50
P356
P1433
P1476
Ring1-mediated ubiquitination ...... valent genes in mouse ES cells
@en
P2093
Amanda G Fisher
Julie K Stock
Sara Giadrossi
P2888
P304
P356
10.1038/NCB1663
P577
2007-11-25T00:00:00Z