about
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genesLeptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob miceCommunicable ulcerative colitis induced by T-bet deficiency in the innate immune systemDeveloping in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's diseaseComplement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.T-bet, a Th1 transcription factor regulates the expression of Tim-3.Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.Genetic loci influencing kidney function and chronic kidney diseaseIntegration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery.A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis.Role and species-specific expression of colon T cell homing receptor GPR15 in colitisRetinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation.Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocolIL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses.T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.A global call for action to include gender in research impact assessmentIn vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responsesAssessment of regulatory T-cell function in forthcoming clinical trials of cell therapy.Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.Relative roles of Th1 and Th17 effector cells in allograft rejection.Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients.Retinoic Acid Signaling in B Cells Is Required for the Generation of an Effective T-Independent Immune Response.The immune cell transcription factor T-bet: A novel metabolic regulator.Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells.The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.Transcriptional regulation of the mucosal immune system mediated by T-bet.Transcriptional control of natural killer cell differentiation and function.The challenges of stratifying patients for trials in inflammatory bowel disease.T-bet: a bridge between innate and adaptive immunity.
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Graham M Lord
@ast
Graham M Lord
@en
Graham M Lord
@es
Graham M Lord
@nl
type
label
Graham M Lord
@ast
Graham M Lord
@en
Graham M Lord
@es
Graham M Lord
@nl
altLabel
Graham Lord
@en
prefLabel
Graham M Lord
@ast
Graham M Lord
@en
Graham M Lord
@es
Graham M Lord
@nl
P106
P21
P31
P496
0000-0003-2069-4743