about
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 inductionChlamydia infection depends on a functional MDM2-p53 axisExcitability in the p53 network mediates robust signaling with tunable activation thresholds in single cellsDifferential protein occupancy profiling of the mRNA transcriptome.A synthetic-natural hybrid oscillator in human cellsp53 dynamics control cell fateBasal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.Dynamics of the DNA damage response: insights from live-cell imagingDistinct mechanisms act in concert to mediate cell cycle arrestCell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.Interference of human and Drosophila APP and APP-like proteins with PNS development in DrosophilaWe are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit via FRET in a binary system.Comparing Agent Based Delivery of DNA and PNA FIT-Probes for Multicolor mRNA Imagingp53 dynamics in single cells are temperature-sensitiveDisentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell ImagingStochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency
P50
Q30505355-9A0AB98E-ECB1-494B-97CD-4755C2C6A248Q30601745-193712C2-19D8-4244-9205-6A5103A4A926Q33572789-7FAB3CFD-FCD2-4795-A16F-CFFF89489DFDQ33751471-6A736B1B-7BD9-4EA9-9B70-2185ECA2D372Q34165397-1246E262-E0EE-4391-9F4B-79196F083118Q34173945-BED28667-2E24-4836-A417-E526CF093BB9Q34414003-7E0ABD37-F25C-40B4-86E8-4BA6BCF2B909Q35046887-BBBFCC25-7EC5-4B8F-9508-427CC33F195DQ36387773-A343A02A-E9D7-4451-A7F5-9D044D26DD19Q36720112-7E6649E0-D74A-448F-9319-D042411519DAQ37070651-5C07FB4A-EC44-4C12-942E-D533DEF3E0E3Q37566689-39578AFE-1689-4BDD-A925-2F943DEE2F9DQ37592533-D5D2665F-78D8-4ED2-A76D-99C4BBA5C560Q37946668-ED8956C7-455F-4567-B37F-ECEFBF1D6E2CQ38765522-6772A905-EFC5-404A-BD16-A0DADFF1489FQ38943429-5E4E340B-9B4B-4D5B-A2A9-797639E98A67Q39983426-8041EB0A-B4D5-4205-B5E2-14174CA47BFAQ40101076-DCBAF455-94D8-44BB-B679-EEE1CAD46949Q42076125-F2FC16BF-0A46-4F50-A187-7512139DFF16Q47556336-39A1533D-A8A8-4812-8794-5E16CBC054DDQ48248659-94EDD9BB-6819-4013-A251-578225803EC6Q55248541-9E41F84A-2BFE-4841-9E12-80C93594E240Q57456473-0EEB66FB-ECA7-4E6C-8CEF-8692FBE2B65BQ89454997-F9BB840E-B609-45CF-B54C-1515A3364A12Q91958051-09AB21B8-D425-4790-A5BE-0C64403A388DQ92305723-03A6AAA7-79B1-40E1-B3E2-18DD95D3F979
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alexander Loewer
@ast
Alexander Loewer
@en
Alexander Loewer
@es
Alexander Loewer
@nl
type
label
Alexander Loewer
@ast
Alexander Loewer
@en
Alexander Loewer
@es
Alexander Loewer
@nl
prefLabel
Alexander Loewer
@ast
Alexander Loewer
@en
Alexander Loewer
@es
Alexander Loewer
@nl
P106
P31
P496
0000-0002-8819-3040