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Distinct mechanisms act in concert to mediate cell cycle arrest

Distinct mechanisms act in concert to mediate cell cycle arrest

http://www.wikidata.org/entity/Q37070651

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Cancer systems biology: a network modeling perspective Cell-to-cell variability in cell death: can systems biology help us make sense of it all?Dynamic rendering of the heterogeneous cell response to anticancer treatments Senescence from G2 arrest, revisited Stress-specific response of the p53-Mdm2 feedback loop A general framework for modeling growth and division of mammalian cells Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells Strategic cell-cycle regulatory features that provide mammalian cells with tunable G1 length and reversible G1 arrest.The DREAM complex: master coordinator of cell cycle-dependent gene expression.Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.Dynamical principles of cell-cycle arrest: reversible, irreversible, and mixed strategies.Computational modeling of mammalian signaling networks.Bistability, oscillations, and traveling waves in frog egg extracts.Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication.Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers.Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation Principles of dynamical modularity in biological regulatory networks.Understanding resistance to combination chemotherapy.Role of Computational Modeling in Understanding Cell Cycle Oscillators.To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage.Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response.Analysis of cell cycle dynamics using probabilistic cell cycle models.Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.Mathematical modeling to distinguish cell cycle arrest and cell killing in chemotherapeutic concentration response curves.Miniaturizing bromodeoxyuridine incorporation enables the usage of flow cytometry for cell cycle analysis of adherent tissue culture cells for high throughput screening.Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation.Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.A dynamical framework for complex fractional killing.Quantitative analysis of the effects of iododeoxyuridine and ionising radiation treatment on the cell cycle dynamics of DNA mismatch repair deficient human colorectal cancer cells.Decision making of the p53 network: death by integration.Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound.Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle.The DNA damage response signaling cascade regulates proliferation of the phytopathogenic fungus Ustilago maydis in planta.Recent progress and open challenges in modeling p53 dynamics in single cells.Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

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P2860

Distinct mechanisms act in concert to mediate cell cycle arrest

http://www.wikidata.org/entity/Q37070651

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Distinct mechanisms act in concert to mediate cell cycle arrest

@en

Distinct mechanisms act in concert to mediate cell cycle arrest.

@nl

type

label

Distinct mechanisms act in concert to mediate cell cycle arrest

@en

Distinct mechanisms act in concert to mediate cell cycle arrest.

@nl

prefLabel

Distinct mechanisms act in concert to mediate cell cycle arrest

@en

Distinct mechanisms act in concert to mediate cell cycle arrest.

@nl

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PNAS.0806196106

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Proceedings of the National Academy of Sciences of the United States of America

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Distinct mechanisms act in concert to mediate cell cycle arrest

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Galit Lahav

http://www.w3.org/2001/XMLSchema#string

Gerard J Ostheimer

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Jared E Toettcher

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Michael B Yaffe

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P2860

Analysis of a generic model of eukaryotic cell-cycle regulation

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells

p53 regulates a G2 checkpoint through cyclin B1

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

Cyclin E ablation in the mouse

Enhanced phosphorylation of p53 by ATM in response to DNA damage

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

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785-790

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scholarly article

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10.1073/PNAS.0806196106

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3

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106

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Alexander Loewer

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2009-01-12T00:00:00Z

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23782641

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19139404

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2630102

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