MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.
about
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activationHow cells switch HIPK2 on and offThe human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damageThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activityMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayDifferential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosisApoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategiesRole of HIPK2 in kidney fibrosisAnother fork in the road--life or death decisions by the tumour suppressor p53Engagement of DYRK2 in proper control for cell divisionTargeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alphaIncreased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53.HIPK2: a multitalented partner for transcription factors in DNA damage response and development.Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survivalDownregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1Interplay between Mdm2 and HIPK2 in the DNA damage response.The regulation of the p53-mediated stress response by MDM2 and MDM4.Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Role of p53 serine 46 in p53 target gene regulation.MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifsc-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation.HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradationMUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathwayDNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate controlMDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 functionLevels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stressPERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells.Screening E3 substrates using a live phage display libraryReview of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesisTowards an understanding of the role of p53 in adrenocortical carcinogenesis.Regulation of the DNA damage response by p53 cofactors3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.Updates on HIPK2: a resourceful oncosuppressor for clearing cancerMDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage responseAnalysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties.
P2860
Q24306227-4B7F32AE-0222-4AFF-B542-0108567508CEQ24310662-D287AD94-AEF0-4C3E-AFA2-20E3667E98B1Q24311659-C4523002-D507-49F3-A74C-33591C3A27CAQ24336416-07F3F914-DC56-47F6-B419-0DD0D44760C7Q24337119-1F1DD75C-DFC0-4CB2-9DFE-4FEC3EF3FD6DQ24337839-CF93824E-D230-4D51-B5D8-AC559A74D41CQ24338676-584BF72B-0570-4E5C-92BB-796A2952C04AQ26750639-41FCBBC1-CBC8-4248-AA71-0E6EE21EA418Q26796620-AA08FE1A-E14C-40B9-83DD-8AE5357877AEQ27026310-558748F5-765E-42BB-B22A-66B73F99F2A9Q28081810-6F44E611-51CD-4669-B103-0BAB85BF56F5Q28476020-A41A71D4-1E15-483A-98A9-427A5C17EBD7Q30492386-1E1BCF71-9594-4DCF-A4C7-DCB2ECF44720Q31122379-1D29378F-1465-4D8D-991E-0107CD827B70Q33564142-0F537847-C69D-4199-808E-981A6013A90DQ33638575-A638236C-F37C-45EA-92B7-F2BE68FB7E6FQ33656086-A2F9BADB-F106-4E1F-8201-4246455867AEQ33685413-EC45EBC2-AA0E-4E52-92B8-698A31A05623Q33725442-0CE40DCC-5FD0-43C5-BE53-FA6F5F4BDB7BQ33791305-2AD96500-5C61-4363-A91D-E0795CDC0D82Q33843352-D2340A37-4F56-4D28-8399-9F0255973EB7Q34056383-8B950051-EE04-4D5F-882E-301313B8A1FCQ34158315-5895033C-8614-465B-8230-F7CE790A4567Q34452497-414583BE-1D75-443A-8913-D899DD57E436Q34476585-EF6E8125-98BF-4C47-9B04-6D8459673D52Q34504863-12C6D3CB-1784-41E4-A25D-F2B9048F5FD6Q34783261-BE8D93B8-7D92-4F77-982A-EF1A46A364F2Q34797347-6B717E2B-2BF7-4A73-BFEB-36E55F1E2C08Q34838208-547D3984-4727-4A60-9FDE-270263DD397CQ34863536-9D16A7BE-6A79-40F5-ADFD-83886153B5C0Q34989369-FDA8FB3C-EA84-4BD5-986A-2ABA0A5D27D9Q35006415-B2527CFE-A06A-4613-9A7B-C7CD70FA1ADCQ35017038-5AAA53C0-A52D-4871-B9AB-CB94331042F2Q35089524-4ADF2040-9C5B-42B4-8BD9-D87E83889DDEQ35783751-4A76ABA9-616F-4B04-8FE0-2EC59F8BB67FQ35962630-5211C6C4-78BE-4779-835A-2E3968E2188AQ35994548-B40F70CE-A121-46CE-8526-148810B373C5Q36204714-34F4C9AD-4D07-4EBC-8280-CE756EC644D8Q36474852-49431C28-FC29-45F2-B2DC-6E532CD4A920Q36609221-544F3BCC-CF32-4342-9501-025481C26F4E
P2860
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@en
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@nl
type
label
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@en
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@nl
prefLabel
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@en
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@nl
P2093
P50
P1433
P1476
MDM2-regulated degradation of ...... DNA damage-induced apoptosis.
@en
P2093
Ada Sacchi
Andrea Prodosmo
Francesca Mancini
P304
P356
10.1016/J.MOLCEL.2007.02.008
P577
2007-03-01T00:00:00Z