Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras - Wikidata - awgldk - TriplyDB

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

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The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13II sensitizes Jurkat T cells to Ras-mediated apoptosis Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth Death pathways triggered by activated Ras in cancer cells Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells.The dark side of Ras: regulation of apoptosis.Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?Nonconventional trafficking of Ras associated with Ras signal organization.Evolution of Bcl-2 homology motifs: homology versus homoplasy.Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation BH4 domain of Bcl-2 as a novel target for cancer therapy Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction.Ras and rheb signaling in survival and cell death BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer.Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis.Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia.Inhibition of transcription factor activity by nuclear compartment-associated Bcl-2.Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis.IL-17 Exerts Anti-Apoptotic Effect via miR-155-5p Downregulation in Experimental Autoimmune Encephalomyelitis.Synaptic and non-synaptic mitochondria in hippocampus of adult rats differ in their sensitivity to hypothyroidism.Alpha 5/6 helix domains together with N-terminus determine the apoptotic potency of the Bcl-2 family proteins.Electrical properties of plasma membrane modulate subcellular distribution of K-Ras.

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Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

http://www.wikidata.org/entity/Q57372098

description

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

im Dezember 2002 veröffentlichter wissenschaftlicher Artikel

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scientific article published in Journal of Biological Chemistry

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wetenschappelijk artikel

@nl

наукова стаття, опублікована в грудні 2002

@uk

name

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

@en

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

@nl

type

label

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

@en

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

@nl

prefLabel

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

@en

Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras

@nl

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Journal of Biological Chemistry

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Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras

@en

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Chang-Yan Chen

http://www.w3.org/2001/XMLSchema#string

Douglas V Faller

http://www.w3.org/2001/XMLSchema#string

Linda Deeds

http://www.w3.org/2001/XMLSchema#string

Peihong Ma

http://www.w3.org/2001/XMLSchema#string

Qiang Yu

http://www.w3.org/2001/XMLSchema#string

P2860

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

Bcl-2 targets the protein kinase Raf-1 to mitochondria

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae.

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

Bcl-2 associates with the ras-related protein R-ras p23

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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5775-5785

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scholarly article

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10.1074/JBC.M210202200

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8

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278

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2002-12-10T00:00:00Z

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12477721

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