Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation
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Novel Linear Peptides with High Affinity to αvβ3 Integrin for Precise Tumor Identification.Monocyte adhesion to atherosclerotic matrix proteins is enhanced by Asn-Gly-Arg deamidationHigh Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular DesignPeptide-mediated targeting of cytokines to tumor vasculature: the NGR-hTNF example.Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis.Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects.Systemic and tumor-targeted delivery of siRNA by cyclic NGR and isoDGR motif-containing peptides.Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.Tumor Targeting with an isoDGR-Drug ConjugateSuccinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side ChainDisruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting.
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P2860
Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation
description
наукова стаття, опублікована в червні 2012
@uk
name
Molecular Dynamics Reveal that ...... egrin Allostery and Activation
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type
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Molecular Dynamics Reveal that ...... egrin Allostery and Activation
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prefLabel
Molecular Dynamics Reveal that ...... egrin Allostery and Activation
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P2093
P2860
P50
P356
P1476
Molecular Dynamics Reveal that ...... egrin Allostery and Activation
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P2093
Barbara Valentinis
Catia Traversari
Claudia Asperti
Gian Paolo Rizzardi
Silvia Mari
P2860
P304
P356
10.1002/ANIE.201202032
P407
P577
2012-06-20T00:00:00Z