Structural insights into phosphoinositide 3-kinase catalysis and signalling
about
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5AThe dictyostelium kinome--analysis of the protein kinases from a simple model organism.Structural evolution of the protein kinase-like superfamilyCloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase familyMolecular insights into the membrane-associated phosphatidylinositol 4-kinase IIαMitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesisThe nucleotide-binding site of human sphingosine kinase 1Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gammaA novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingLipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram-negative bacteria are related to the eukaryotic protein kinasesEmerging common themes in regulation of PIKKs and PI3KsPhosphoinositide 3-kinase: a critical signalling event in pulmonary cellsThe repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinationsPKCβ phosphorylates PI3Kγ to activate it and release it from GPCR controlA mathematical model for neutrophil gradient sensing and polarizationStructure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7pCerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase ActivityMechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunitStructural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsStructure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and SelectivityTargeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinasesStructure of the F-spondin domain of mindin, an integrin ligand and pattern recognition moleculeCrystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitorsStructural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinasesmTOR kinase structure, mechanism and regulationDiscovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of RapamycinEngineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug designDiscovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturationRecent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agentsHaspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinasesPI3K/PTEN signaling in angiogenesis and tumorigenesisAssociation rate constants of ras-effector interactions are evolutionarily conservedAnalysis of the catalytic domain of phosphatidylinositol 4-kinase type II
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Structural insights into phosphoinositide 3-kinase catalysis and signalling
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в листопаді 1999
@uk
name
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@en
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@nl
type
label
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@en
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@nl
prefLabel
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@en
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@nl
P2093
P356
P1433
P1476
Structural insights into phosphoinositide 3-kinase catalysis and signalling
@en
P2093
P2888
P304
P356
10.1038/46319
P407
P577
1999-11-18T00:00:00Z
P6179
1046130490