Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors
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Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signalingStructures of Legionella pneumophila NTPDase1 in complex with polyoxometallatesCharacterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 : partial characterization of the inhibitory epitope and potential applicationsOsmotic surveillance mediates rapid wound closure through nucleotide release.Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulenceCystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation.Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody.Ticlopidine in its prodrug form is a selective inhibitor of human NTPDase1CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in miceIncreased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension.Synthesis, characterization and bioimaging of fluorescent labeled polyoxometalates.Purinergic mechanisms in gliovascular couplingATP hydrolysis pathways and their contributions to pial arteriolar dilation in rats.CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma.The role of ATP and adenosine in the brain under normoxic and ischemic conditionsMetabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activitiesEnzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts.Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications.Ectonucleotidases in the kidney.Activity-dependent release of adenosine: a critical re-evaluation of mechanism.Therapeutic interventions ameliorating prion disease.Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells.ENTPD1/CD39 is a promising therapeutic target in oncology.Immunotherapeutic approaches in prion disease: progress, challenges and potential directions.Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/phosphodiesterase, ecto-5'-nucleotidase, and alkaline phosphatase inhibitors.Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody.New crystal forms of NTPDase1 from the bacterium Legionella pneumophilaIdentification of polyoxometalates as inhibitors of basic fibroblast growth factor.Polyoxometalates as inhibitors of the aggregation of amyloid β peptides associated with Alzheimer's disease.Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.8-BuS-ATP derivatives as specific NTPDase1 inhibitors.Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices.A commonly used ecto-ATPase inhibitor, ARL-67156, blocks degradation of ADP more than the degradation of ATP in murine colonCytotoxicity and enzyme inhibition studies of polyoxometalates and their chitosan nanoassemblies.Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine.PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases.Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors.Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases).
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Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors
description
im Dezember 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 25 September 2006
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2006
@uk
name
Polyoxometalates—a new class o ...... hydrolase (NTPDase) inhibitors
@en
Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase
@nl
type
label
Polyoxometalates—a new class o ...... hydrolase (NTPDase) inhibitors
@en
Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase
@nl
prefLabel
Polyoxometalates—a new class o ...... hydrolase (NTPDase) inhibitors
@en
Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase
@nl
P2093
P50
P1476
Polyoxometalates--a new class ...... hydrolase (NTPDase) inhibitors
@en
P2093
Anita Röllich
Herbert Zimmermann
Jamshed Iqbal
P304
P356
10.1016/J.BMCL.2006.09.003
P407
P577
2006-09-25T00:00:00Z