Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead
about
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targetsTargeting survivin in cancer therapyA novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activityInvestigating the dynamic aspects of drug-protein recognition through a combination of MD and NMR analyses: implications for the development of protein-protein interaction inhibitorsPredicting interaction sites from the energetics of isolated proteins: a new approach to epitope mapping.Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.Small molecule DnaK modulators targeting the beta-domain.Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markersInhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells.Prostate cancer regulatory networksCombined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach.Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution.Inhibitors of the heat shock response: biology and pharmacology.IAP-targeted therapies for cancer.Recent Advances on Small-Molecule Survivin Inhibitors.Targeting survivin in cancer: patent review.Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitorsMolecular dynamics simulations of hsp90 with an eye to inhibitor design.5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects.Heat-shock protein 90 (Hsp90) as anticancer target for drug discovery: an ample computational perspective.Therapeutic Effects of AICAR and DOX Conjugated Multifunctional Nanoparticles in Sensitization and Elimination of Cancer Cells via Survivin Targeting.Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy.Ligand selection from the analysis of protein conformational substates: new leads targeting the N-terminal domain of Hsp902′-O-Alkyl Derivatives and 5′-Analogues of 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) as Potential Hsp90 InhibitorsTargeting Difficult Protein-Protein Interactions with Plain and General Computational Approaches
P2860
Q24304999-61F50615-F3D9-46D9-922F-A35832A01BB9Q28273083-949AA85B-7EFC-4A58-BACC-7C521E0C802AQ28483886-67AD0E40-9183-4A8F-ACE8-12E4788EF081Q28539120-29B94DD4-9043-497B-879F-90B1B87E4EEEQ30388806-30FC9AE9-12A1-48D3-8F3C-0B615F7D81E8Q30493655-96679DAC-B472-440A-9FBF-BC97DBD67E5DQ33495332-0CF52427-DC87-42E5-BB15-24779419B51FQ33745108-1ED9C714-6E03-4169-95BA-87BE43F29B67Q33811146-3E7760BE-ECBF-4686-9DC9-9BAE6961D2FEQ33864137-70A278AD-D91B-44F1-AA59-0FB3AAFDA071Q33960568-CA816A79-3AE2-4640-B37B-0B86B93D5E46Q34192823-773611B4-E19F-42AA-B6E0-B6B4B7A7F042Q35800838-F3ECB849-DD91-41F2-BDD4-960FD751E2ABQ36259861-981621F2-4CBE-49CF-B720-7FACBF3358B5Q36685831-D5751A2B-BFEC-401C-9EE3-52176278D268Q36845355-7774302D-96E5-4A24-8E67-91315F5CEDAAQ37302745-03946174-6401-465B-BA0F-02781423601DQ37689286-874F8889-734B-4823-8035-B0071F6499E2Q37810294-8166800B-D12B-4C99-9B43-B4912E0DF762Q37840948-6F1C4455-8EAF-416F-B9CB-610591B16EB3Q38166531-7C4F1A11-41B2-4D05-8E4F-9E9F352A112DQ38222605-73BEA733-EA6B-482C-9449-563CDB3D80CCQ38469746-FADA6CF8-C9E4-4F83-A393-62BF3B9F7C4FQ39248016-8764C0AA-677F-49B0-BC64-03AF4DEC9968Q42949488-65C6A0EF-4527-40FD-8490-4DEDA7340ADCQ57794695-A9D8DCDC-16F6-43A8-A211-8B0F8EF0BB23Q57794839-01E3E0A5-B64F-4950-B7C9-3553D00AABEBQ58691534-9BBECA99-6014-4EC7-8341-93F28BE46423
P2860
Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer Lead
description
im Dezember 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 December 2006
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2006
@uk
name
Small-Molecule Targeting of He ...... ation of a New Anticancer Lead
@en
Small-Molecule Targeting of He ...... ation of a New Anticancer Lead
@nl
type
label
Small-Molecule Targeting of He ...... ation of a New Anticancer Lead
@en
Small-Molecule Targeting of He ...... ation of a New Anticancer Lead
@nl
prefLabel
Small-Molecule Targeting of He ...... ation of a New Anticancer Lead
@en
Small-Molecule Targeting of He ...... ation of a New Anticancer Lead
@nl
P2093
P50
P356
P1476
Small-molecule targeting of he ...... ation of a new anticancer lead
@en
P2093
Dario C Altieri
Janet Plescia
Maria Curto
P304
P356
10.1021/JM060836Y
P407
P577
2006-12-01T00:00:00Z