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Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphatesPTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosolThe protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signalingHeregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cellsPhosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolinHeregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptorInterleukin-4 alters early phagosome phenotype by modulating class I PI3K dependent lipid remodeling and protein recruitmentAll Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway.From preadipocyte to adipocyte: differentiation-directed signals of insulin from the cell surface to the nucleus.Signaling pathways mediating insulin-stimulated glucose transport.Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain.Genomics, complexity and drug discovery: insights from Boolean network models of cellular regulation.Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.Growth hormone signal transduction.Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications.Oncogenic Ras in tumour progression and metastasis.Role of HER2/HER3 co-receptor in breast carcinogenesis.Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinaseDifferential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).A new recombinant pituitary adenylate cyclase-activating peptide-derived peptide efficiently promotes glucose uptake and glucose-dependent insulin secretion.Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway.The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.Expression of cyclooxygenase 2 by prostaglandin E(2) in human endometrial adenocarcinoma cell line HEC-1B.Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism.mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control.The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.Induction of tube formation by angiopoietin-1 in endothelial cell/fibroblast co-culture is dependent on endogenous VEGF.Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp.Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/Akt/FOXO3a Signaling Pathway.Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation.MAP kinase 1/2 (Erk 1/2) and serine/threonine specific protein kinase Akt/PKB expression and activity in the human corpus cavernosum.Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras.The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells.Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.
P2860
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P2860
description
article publié dans la revue scientifique Science
@fr
im Januar 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 1998
@uk
name
Lipid-Regulated Kinases: Some Common Themes at Last
@en
Lipid-Regulated Kinases: Some Common Themes at Last
@nl
type
label
Lipid-Regulated Kinases: Some Common Themes at Last
@en
Lipid-Regulated Kinases: Some Common Themes at Last
@nl
prefLabel
Lipid-Regulated Kinases: Some Common Themes at Last
@en
Lipid-Regulated Kinases: Some Common Themes at Last
@nl
P1433
P1476
Lipid-regulated kinases: some common themes at last
@en
P304
P356
10.1126/SCIENCE.279.5351.673
P407
P577
1998-01-01T00:00:00Z