Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability
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Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsThe relationship between amyloid structure and cytotoxicityModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsChemically and thermally stable silica nanowires with a β-sheet peptide core for bionanotechnologyLysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid ProteinsThe C-terminal amyloidogenic peptide contributes to self-assembly of Avibirnavirus viral proteaseAcetylation: a new key to unlock tau's role in neurodegenerationAromaticity and amyloid formation: effect of π-electron distribution and aryl substituent geometry on the self-assembly of peptides derived from hIAPP(22-29).Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomesHow ionic strength affects the conformational behavior of human and rat beta amyloids--a computational studyRole of sequence and structural polymorphism on the mechanical properties of amyloid fibrilsRole of hydration force in the self-assembly of collagens and amyloid steric zipper filamentsBrazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity.Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease.Silica Nanowires Templated by Amyloid-like FibrilsTyrosine residues mediate fibril formation in a dynamic light chain dimer interface.Solvent-induced tuning of internal structure in a protein amyloid protofibril.Lack of Dependence of the Sizes of the Mesoscopic Protein Clusters on ElectrostaticsEvidence of π-stacking interactions in the self-assembly of hIAPP(22-29).Role of Berberine in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections.Ionic strength effects on amyloid formation by amylin are a complicated interplay among Debye screening, ion selectivity, and Hofmeister effectsStructure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain.Melanosomal formation of PMEL core amyloid is driven by aromatic residues.Intrinsically disordered proteins and novel strategies for drug discovery.Self-assembly of amphipathic β-sheet peptides: insights and applications.Exploring critical determinants of protein amyloidogenesis: a review.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.Disruption of diphenylalanine assembly by a Boc-modified variant.A carboxylated Zn-phthalocyanine inhibits fibril formation of Alzheimer's amyloid β peptide.The importance of being Aib. Aggregation and self-assembly studies on conformationally constrained oligopeptides.Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle FormationA covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β.Designing peptidic inhibitors of serum amyloid A aggregation process.A Phe-rich region in short-wavelength sensitive opsins is responsible for their aggregation in the absence of 11-cis-retinal.Silica Nanowires Templated by Amyloid-like Fibrils.Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases.The impact of solubility and electrostatics on fibril formation by the H3 and H4 histones.
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Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability
description
im März 2011 veröffentlicher wissenschaftlicher Artikel
@de
scientific article published on 22 February 2011
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2011
@uk
name
Hydrophobic, Aromatic, and Ele ...... Fibril Formation and Stability
@en
Hydrophobic, Aromatic, and Ele ...... Fibril Formation and Stability
@nl
type
label
Hydrophobic, Aromatic, and Ele ...... Fibril Formation and Stability
@en
Hydrophobic, Aromatic, and Ele ...... Fibril Formation and Stability
@nl
prefLabel
Hydrophobic, Aromatic, and Ele ...... Fibril Formation and Stability
@en
Hydrophobic, Aromatic, and Ele ...... Fibril Formation and Stability
@nl
P2093
P356
P1433
P1476
Hydrophobic, aromatic, and ele ...... fibril formation and stability
@en
P2093
Deborah Charlton
Helen Walden
Karen E Marshall
Kyle L Morris
Laurence Lewis
Nicola O'Reilly
P304
P356
10.1021/BI101936C
P407
P577
2011-02-22T00:00:00Z