Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways
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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseCrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effectsType 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosisImproving Cell Engraftment in Cardiac Stem Cell TherapyRegulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinaseExtracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)The effect of 15-lipoxygenase-1 expression on cancer cellsAbrin triggers cell death by inactivating a thiol-specific antioxidant proteinMesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathwayInteraction of the Grb10 adapter protein with the Raf1 and MEK1 kinasesA gain-of-function germline mutation in Drosophila ras1 affects apoptosis and cell fate during developmentERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neuronsRegeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis.NO protects alveolar type II cells from stretch-induced apoptosis. A novel role for macrophages in the lung.Inhibition of insulin-like growth factor-1 receptor and IRS-2 signaling by ethanol in SH-SY5Y neuroblastoma cells.Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts.Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis.QTL region-specific microarrays reveal differential expression of positional candidate genes of signaling pathways associated with the liability for the inverted teat defect.A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage.Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival.Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis.Deficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblastsType I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cellsAttenuated cardiac mitochondrial-dependent apoptotic effects by li-fu formula in hamsters fed with a hypercholesterol diet.Apoptosis in lung development and neonatal lung injury.Involvement of growth factors in thymic involution.Body mass index associated with genome-wide methylation in breast tissue.Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampusTargeting the insulin-like growth factor receptor pathway in lung cancer: problems and pitfalls.A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loopExtracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix.Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cellsAnti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart.How membrane dysfunction influences neuronal survival pathways in sphingolipid storage disordersRole of IGF-1 in glucose regulation and cardiovascular disease.Cardioprotective growth factors.
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Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Januar 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 1997
@uk
name
Insulin-like Growth Factor 1 I ...... ivated Protein Kinase Pathways
@en
Insulin-like Growth Factor 1 I ...... ivated Protein Kinase Pathways
@nl
type
label
Insulin-like Growth Factor 1 I ...... ivated Protein Kinase Pathways
@en
Insulin-like Growth Factor 1 I ...... ivated Protein Kinase Pathways
@nl
prefLabel
Insulin-like Growth Factor 1 I ...... ivated Protein Kinase Pathways
@en
Insulin-like Growth Factor 1 I ...... ivated Protein Kinase Pathways
@nl
P356
P1476
Insulin-like growth factor 1 i ...... ivated protein kinase pathways
@en
P2093
P304
P356
10.1074/JBC.272.1.154
P407
P577
1997-01-01T00:00:00Z