The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
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The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brainNrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagyTcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteinsStress-activated cap'n'collar transcription factors in aging and human diseaseExtracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegansDifferent susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel.Caenorhabditis elegans: A useful model for studying metabolic disorders in which oxidative stress is a contributing factor.NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's diseaseSanguisorbae radix protects against 6-hydroxydopamine-induced neurotoxicity by regulating NADPH oxidase and NF-E2-related factor-2/heme oxygenase-1 expressions.Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Isolation of a Hypomorphic skn-1 Allele That Does Not Require a Balancer for Maintenance.Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's DiseaseRenoprotective effect of the antioxidant curcumin: Recent findings.Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons.Targeting mitochondrial dysfunction in neurodegenerative disease: Part I.Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases.Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke.Defective autophagy in Parkinson's disease: role of oxidative stress.New insights into antioxidant strategies against paraquat toxicity.Paradoxical cellular effects and biological role of the multifaceted compound nordihydroguaiaretic acid.Mitochondria as a target in the therapeutic properties of curcumin.In vivo delivery of transcription factors with multifunctional oligonucleotides.Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex().Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson's Disease Through Upregulating Nrf2.6-OHDA-Induced Changes in Parkinson's Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells.SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease.Antioxidant defense of Nrf2 vs pro-inflammatory system of NF-κB during the amoebic liver infection in hamster.Phytoestrogen β-Ecdysterone Protects PC12 Cells Against MPP+-Induced Neurotoxicity In Vitro: Involvement of PI3K-Nrf2-Regulated Pathway.Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation.Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2.Lutein alleviates arsenic-induced reproductive toxicity in male mice via Nrf2 signaling.NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage.Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee.Nrf2, a guardian of healthspan and gatekeeper of species longevity.Silencing of Hsp90 chaperone expression protects against 6-hydroxydopamine toxicity in PC12 cells.The attenuating effects of plumbagin on pro-inflammatory cytokine expression in LPS-activated BV-2 microglial cells.Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich's Ataxia.Microarray Analysis of the Molecular Mechanism Involved in Parkinson's Disease.
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The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
description
im März 2009 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2009
@uk
name
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@en
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@nl
type
label
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@en
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@nl
prefLabel
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@en
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@nl
P2860
P1476
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
@en
P2093
José Pedraza-Chaverri
Paz Moreno-Murciano
P2860
P304
P356
10.1517/13543780802716501
P407
P577
2009-03-01T00:00:00Z