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Dynamic Visualization of Thrombopoiesis Within Bone Marrow

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

http://www.wikidata.org/entity/Q58450371

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Platelet generation in vivo and in vitro Megakaryocytes, malignancy and bone marrow vascular niches Transcription factors in late megakaryopoiesis and related platelet disorders Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.Terminal platelet production is regulated by von Willebrand factor Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming Three-Dimensional Environment Sustains Hematopoietic Stem Cell Differentiation into Platelet-Producing Megakaryocytes Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation Platelets Guide Leukocytes to Their Sites of Extravasation Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful.Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin Integrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three-Dimensional Rotary Culture System.In vivo longitudinal visualization of bone marrow engraftment process in mouse calvaria using two-photon microscopy.Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.Induced pluripotent stem cell-derived human platelets: one step closer to the clinic Covalently immobilized glycosaminoglycans enhance megakaryocyte progenitor expansion and platelet release Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Cellular-based therapies to prevent or reduce thrombocytopenia.Inherited thrombocytopenias: an approach to diagnosis and management.Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside.ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.Improved quantitative analysis of primary bone marrow megakaryocytes utilizing imaging flow cytometry.Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders.Molecular basis of inherited thrombocytopenias.Manipulating megakaryocytes to manufacture platelets ex vivo.A novel bioreactor and culture method drives high yields of platelets from stem cells.Thrombopoietic status of patients on haemodialysis.

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Dynamic Visualization of Thrombopoiesis Within Bone Marrow

http://www.wikidata.org/entity/Q58450371

description

article publié dans la revue scientifique Science

@fr

im September 2007 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published in Science

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована у вересні 2007

@uk

name

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

@en

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

@nl

type

label

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

@en

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

@nl

prefLabel

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

@en

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

@nl

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SCIENCE.1146304

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P1476

Dynamic visualization of thrombopoiesis within bone marrow

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Denisa D Wagner

http://www.w3.org/2001/XMLSchema#string

Harald Schulze

http://www.w3.org/2001/XMLSchema#string

Joseph E Italiano

http://www.w3.org/2001/XMLSchema#string

Ramesh A Shivdasani

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Steffen Massberg

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Tobias Goerge

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Tobias Junt

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Ulrich H von Andrian

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Zhao Chen

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P2860

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.

The biogenesis of platelets from megakaryocyte proplatelets.

Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.

In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets?

THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS.

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1.

CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation.

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1767-1770

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scholarly article

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10.1126/SCIENCE.1146304

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5845

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317

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Andreas Krueger

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2007-09-01T00:00:00Z

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17885137

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