Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion - Wikidata - awgldk - TriplyDB

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

http://www.wikidata.org/entity/Q59066328

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Transcriptional analysis of the B cell germinal center reaction Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching Role of the intestinal cytokine microenvironment in shaping the intraepithelial lymphocyte repertoire Foxp1 is an essential transcriptional regulator of B cell development An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool.Maturation-dependent licensing of naive T cells for rapid TNF production.Receptor editing in peripheral B cell tolerance.Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.Review article: role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development.The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.Revising B cell receptors Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells Deletion of immunoglobulin beta in developing B cells leads to cell death.Lymphoid malignancies: the dark side of B-cell differentiation.Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus.RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes Mechanisms of chromosomal translocations in B cell lymphomas.Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions.Receptor revision and systemic lupus.Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.Thymic output in aged mice.Transgenic and gene targeting studies of hair cell function in mouse inner ear.Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes The role of DNA breaks in genomic instability and tumorigenesis.Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.Lipid phosphate phosphatase 3 enables efficient thymic egress.B-cell antigen-receptor signalling in lymphocyte development.Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.Regulation of activation and recombination of the murine Igkappa locus.Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.Thymus-autonomous T cell development in the absence of progenitor import.50 million years of chordate evolution: seeking the origins of adaptive immunity.Thymic emigration revisited A role for AID in chromosome translocations between c-myc and the IgH variable region.Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production.

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Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

http://www.wikidata.org/entity/Q59066328

description

article publié dans la revue scientifique Nature

@fr

scientific article published in Nature

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в Nature в серпні 1999

@uk

name

Continued RAG expression in la ...... re-induction after immunizion

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Continued RAG expression in la ...... re-induction after immunizion

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type

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Continued RAG expression in la ...... re-induction after immunizion

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Continued RAG expression in la ...... e-induction after immunization

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Jankovic M

http://www.w3.org/2001/XMLSchema#string

Meffre E

http://www.w3.org/2001/XMLSchema#string

Melchers F

http://www.w3.org/2001/XMLSchema#string

Misulovin Z

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Nagaoka H

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Nussenzweig MC

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Rolink A

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Suh H

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Yu W

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P2860

Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow

The V(D)J recombination activating gene, RAG-1.

V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

Receptor editing: an approach by autoreactive B cells to escape tolerance.

Receptor editing in self-reactive bone marrow B cells.

Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells.

Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.

Peripheral deletion of self-reactive B cells.

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682-687

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scholarly article

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10.1038/23287

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6745

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400

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Michel C. Nussenzweig

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1999-08-01T00:00:00Z

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1017730478

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10458165

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