Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells
about
Human perforin employs different avenues to damage membranesPerforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defenseKilling of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer ProteinsNK cells and apoptosis.Perforin rapidly induces plasma membrane phospholipid flip-flopDelivery and therapeutic potential of human granzyme B.Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within EuteleostomiEffects of MACPF/CDC proteins on lipid membranes.Perforin deficiency and susceptibility to cancer.Perforin activity at membranes leads to invaginations and vesicle formation.Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene.Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding.A molecular-genetic analysis of cytotoxic T lymphocyte function.Killing machines: three pore-forming proteins of the immune system.Natural killer cell receptors: alterations and therapeutic targeting in malignancies.The molecular basis of target cell killing by human lymphocytes and of killer cell self-protection.Role of soluble cytotoxic factors in lymphokine-activated killer cell (LAK)-mediated cytotoxicity.Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes.Molecular mechanisms of CTL-mediated lysis: a cellular perspective.Activation of CTL-specific genes during cell-mediated cytolysis in vivo: expression of the HF gene analyzed by in situ hybridization.Measuring kinetic drivers of pneumolysin pore structure.Finding a Balance between Protection and Pathology: The Dual Role of Perforin in Human Disease.Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp.Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.Molecular mechanism of target lysis by cytotoxic T cells.Cholera toxin inhibits lethal hit stage of natural killer cell-mediated cytotoxicity.Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
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P2860
Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в березні 1983
@uk
name
Assembly of two types of tubul ...... by cloned natural killer cells
@en
Assembly of two types of tubul ...... by cloned natural killer cells
@nl
type
label
Assembly of two types of tubul ...... by cloned natural killer cells
@en
Assembly of two types of tubul ...... by cloned natural killer cells
@nl
prefLabel
Assembly of two types of tubul ...... by cloned natural killer cells
@en
Assembly of two types of tubul ...... by cloned natural killer cells
@nl
P356
P1433
P1476
Assembly of two types of tubul ...... by cloned natural killer cells
@en
P2093
P2888
P304
P356
10.1038/302442A0
P407
P577
1983-03-01T00:00:00Z
P6179
1051224609