New Paradigm for Lymphocyte Granule-mediated Cytotoxicity - Wikidata - awgldk - TriplyDB

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

http://www.wikidata.org/entity/Q59156993

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Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3 Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation Defining the interaction of perforin with calcium and the phospholipid membrane Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes Cytotoxic proteins and therapeutic targets in severe cutaneous adverse reactions Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737 Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.Definition and redesign of the extended substrate specificity of granzyme B.Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.Cell death induced by the Fas/Fas ligand pathway and its role in pathology.The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.Granzyme A activates another way to die Perforin rapidly induces plasma membrane phospholipid flip-flop Profiling protein function with small molecule microarrays.Delivery and therapeutic potential of human granzyme B.Protocatechuic aldehyde inhibits lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis via regulation of caspase-3.Effects of MACPF/CDC proteins on lipid membranes.Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.Cell-mediated cytotoxicity in recovery from poxvirus infections.Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells.Perforin: structure, function, and role in human immunopathology.Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Granzyme B: a natural born killer.Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.Perforin activity at membranes leads to invaginations and vesicle formation.Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis.Perforin and lymphohistiocytic proliferative disorders.Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis Perforin and Fas/FasL cytolytic pathways at the maternal-fetal interface.Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

http://www.wikidata.org/entity/Q59156993

description

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

im November 1996 veröffentlichter wissenschaftlicher Artikel

@de

scientific article published in Journal of Biological Chemistry

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в листопаді 1996

@uk

name

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

@en

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

@nl

type

label

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

@en

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

@nl

prefLabel

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

@en

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

@nl

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JBC.271.46.29073

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Journal of Biological Chemistry

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

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Bernard Babior

http://www.w3.org/2001/XMLSchema#string

Christopher J. Froelich

http://www.w3.org/2001/XMLSchema#string

Girish M. Shah

http://www.w3.org/2001/XMLSchema#string

Jane Turbov

http://www.w3.org/2001/XMLSchema#string

Prem Seth

http://www.w3.org/2001/XMLSchema#string

R. Christopher Bleackley

http://www.w3.org/2001/XMLSchema#string

Roberta Gottlieb

http://www.w3.org/2001/XMLSchema#string

Vishva M. Dixit

http://www.w3.org/2001/XMLSchema#string

William Hanna

http://www.w3.org/2001/XMLSchema#string

P2860

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

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29073-29079

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scholarly article

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10.1074/JBC.271.46.29073

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46

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271

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1996-11-15T00:00:00Z

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