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Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's diseaseStructure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasisMetal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domainKinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes proteinEvidence for a copper-binding superfamily of the amyloid precursor proteinDisturbed copper bioavailability in Alzheimer's diseaseProteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancerStructural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac SulfideIdentification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosisThe amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic miceIs there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors?Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization.Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification.The proton-pump inhibitor lansoprazole enhances amyloid beta production.Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors.Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease.Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zincSuppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.Involvement of amyloid beta precursor protein (AbetaPP) modulated copper homeostasis in Alzheimer's disease.Amyloid precursor protein and BACE function as oligomers.Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer's Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity.Copper transport mediated by nanocarrier systems in a blood-brain barrier in vitro model.Light-controlled toxicity of engineered amyloid β-peptides.Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways.Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallinDimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.Human BACE forms dimers and colocalizes with APP.
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P50
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researcher ORCID ID = 0000-0003-1373-0048
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wetenschapper
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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G Multhaup
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G. Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
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Gerd Multhaup
@nl
P106
P21
P214
11145602345001360556
P31
P496
0000-0003-1373-0048
P7859
viaf-11145602345001360556