about
Interleukin-33 and the function of innate lymphoid cellsMutant Escherichia coli heat-labile toxin B subunit that separates toxoid-mediated signaling and immunomodulatory action from trafficking and delivery functionsImmune modulation by the cholera-like enterotoxins.SHP2 forecast for the immune system: fog gradually clearing.Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.The B subunit of Escherichia coli heat-labile enterotoxin induces both caspase-dependent and -independent cell death pathways in CD8+ T cellsThe influence of mTOR on T helper cell differentiation and dendritic cell function.Innate lymphoid cells in type 2 immune responses.Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 PhosphorylationIL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin.Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation?MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas.Selective induction of CD8+CD4- thymocyte apoptosis mediated by the B-subunit of Escherichia coli heat-labile enterotoxin.Type 2 innate lymphoid cells drive CD4+ Th2 cell responses.CD4+ T cell hyper-responsiveness in CD45 transgenic mice is independent of isoform.The src homology 2 domain-containing tyrosine phosphatase 2 regulates primary T-dependent immune responses and Th cell differentiation.Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking.Fyn regulates the duration of TCR engagement needed for commitment to effector function.The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation.mTOR Regulation of Glycolytic Metabolism in T CellsTargeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy
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description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-1807-1056
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researcher ORCID ID = 0000-0002-1807-1056
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Robert J Salmond
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Robert J Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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type
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Robert J Salmond
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Robert J Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert J Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
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Robert Salmond
@ceb
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P21
P31
P496
0000-0002-1807-1056