The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.
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The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cellsT cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceRegulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLLThe Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular DifferentiationElucidating the immunological function of the Cryptococcus neoformans capsuleThe tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisT cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatasesThe phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating LckSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsReduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death.Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45Role of CD45 signaling pathway in galactoxylomannan-induced T cell damage.T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentProtein tyrosine phosphatases as potential therapeutic targets.Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clustersConstitutively active Lck kinase in T cells drives antigen receptor signal transductionCD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsRegulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.Small molecule inhibition of Csk alters affinity recognition by T cells.The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase LckT cell Receptor Signal Transduction in T lymphocytes.Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) AutoregulationSelective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.CD45 glycosylation controls T-cell life and death.Maturation and emigration of single-positive thymocytes.Lipid rafts and T-lymphocyte function: implications for autoimmunity.Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells.
P2860
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P2860
The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
The differential regulation of ...... receptor signaling responses.
@en
The differential regulation of ...... receptor signaling responses.
@nl
type
label
The differential regulation of ...... receptor signaling responses.
@en
The differential regulation of ...... receptor signaling responses.
@nl
prefLabel
The differential regulation of ...... receptor signaling responses.
@en
The differential regulation of ...... receptor signaling responses.
@nl
P2093
P1433
P1476
The differential regulation of ...... receptor signaling responses.
@en
P2093
Céline K Carret
Denis R Alexander
Joanne C Cooper
Louise McNeill
Marta Roche-Molina
Nick Holmes
Panna Tandon
Robin L Cassady-Cain
P304
P356
10.1016/J.IMMUNI.2007.07.015
P407
P577
2007-08-23T00:00:00Z