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The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complexThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsTwo PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingSMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanGW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targetsDeadenylation is a widespread effect of miRNA regulationStaphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanismCrystal structure of the MID-PIWI lobe of a eukaryotic Argonaute proteinA direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradationStructure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteinsAn asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decayTarget-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.The poly(A) binding protein Hfq protects RNA from RNase E and exoribonucleolytic degradation.The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs.Getting to the root of miRNA-mediated gene silencing.The role of GW182 proteins in miRNA-mediated gene silencing.miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning.The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release.Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms.Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu.GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay.Staphylococcus aureus endoribonuclease III purification and properties.Erratum: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay
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P50
name
Eric Huntzinger
@ast
Eric Huntzinger
@en
Eric Huntzinger
@nl
type
label
Eric Huntzinger
@ast
Eric Huntzinger
@en
Eric Huntzinger
@nl
prefLabel
Eric Huntzinger
@ast
Eric Huntzinger
@en
Eric Huntzinger
@nl