Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
about
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundancemiRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsExonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNADistinct functions of maternal and somatic Pat1 protein paralogsThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsTwo PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingThe C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoaGW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylationMiR-205 silences MED1 in hypoxic primary human trophoblastsKinetic signatures of microRNA modes of actionGenomic screening with RNAi: results and challengesThe let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiationDeadenylation of maternal mRNAs mediated by miR-427 in Xenopus laevis embryosDeadenylation is a widespread effect of miRNA regulationA divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targetingNew insights into decapping enzymes and selective mRNA decayThe C-terminal region of Ge-1 presents conserved structural features required for P-body localizationSimilar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein ComplexesThe RRM domain in GW182 proteins contributes to miRNA-mediated gene silencingDCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoaActive Site Conformational Dynamics Are Coupled to Catalysis in the mRNA Decapping Enzyme Dcp2A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradationMammalian microRNAs predominantly act to decrease target mRNA levelsDecapping activators in Saccharomyces cerevisiae act by multiple mechanisms.Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.Drosophila Ge-1 promotes P body formation and oskar mRNA localizationAutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarityEdc3 function in yeast and mammals is modulated by interaction with NAD-related compoundsIntracellular localization and interaction of mRNA binding proteins as detected by FRET.ProteoMirExpress: inferring microRNA and protein-centered regulatory networks from high-throughput proteomic and mRNA expression dataConcordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNAmicroRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity.A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancerIdentification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiaeGlobal phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3Role of specific microRNAs in regulation of vascular smooth muscle cell differentiation and the response to injuryWidespread translational inhibition by plant miRNAs and siRNAs.Involvement of microRNAs in the regulation of muscle wasting during catabolic conditions.MicroRNA-1 regulates chondrocyte phenotype by repressing histone deacetylase 4 during growth plate development.
P2860
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P2860
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@ast
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@en
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@nl
type
label
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@ast
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@en
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@nl
prefLabel
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@ast
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@en
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@nl
P2093
P2860
P50
P356
P1433
P1476
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.
@en
P2093
Michael Boutros
Mona Stricker
Schu-Fee Yang
Silke Dorner
P2860
P304
P356
10.1101/GAD.443107
P5008
P577
2007-09-27T00:00:00Z