about
The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II.A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activationCrystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITYStructural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt SignalingTankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose ModificationRPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunitsPARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome.Functional dissection of the catalytic mechanism of mammalian RNA polymerase II.Structural perspective on mutations affecting the function of multisubunit RNA polymerases.Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.The RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation.Photo-cross-linking of a purified preinitiation complex reveals central roles for the RNA polymerase II mobile clamp and TFIIE in initiation mechanisms.[Focus on RNA polymerase II].Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis.Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis.Inhibitors of Multisubunit RNA Polymerases as Tools to Study Transcriptional Mechanisms in Prokaryotes and Eukaryotes
P50
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P50
name
Marie-France Langelier
@ast
Marie-France Langelier
@en
Marie-France Langelier
@nl
type
label
Marie-France Langelier
@ast
Marie-France Langelier
@en
Marie-France Langelier
@nl
prefLabel
Marie-France Langelier
@ast
Marie-France Langelier
@en
Marie-France Langelier
@nl