The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
about
PARPs and the DNA damage responseCrystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITYThe DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc FingerStructural studies of the PARP-1 BRCT domainStructural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1Crystal Structure of Human ADP-ribose Transferase ARTD15/PARP16 Reveals a Novel Putative Regulatory DomainThe zinc-finger domains of PARP1 cooperate to recognize DNA strand breaksADP-ribosyltransferases and poly ADP-ribosylationStructural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.Functional Aspects of PARP1 in DNA Repair and Transcription.PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase.Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases.New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase.Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomesDual roles of PARP-1 promote cancer growth and progression.PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damagePoly-ADP-ribose polymerase: machinery for nuclear processes.Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1.Structural Implications for Selective Targeting of PARPs.Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.PARP-1 and PARP-2: New players in tumour development.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.The recognition and removal of cellular poly(ADP-ribose) signals.Tankyrases: structure, function and therapeutic implications in cancer.Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities.The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival.Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response.Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses.DNA-dependent SUMO modification of PARP-1PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity.Up-regulation of two distinct p53-DNA binding functions by covalent poly(ADP-ribosyl)ation: transactivating and single strand break sensing.
P2860
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P2860
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@ast
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@en
type
label
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@ast
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@en
prefLabel
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@ast
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@en
P2093
P2860
P356
P1476
The Zn3 domain of human poly(A ...... vity and chromatin compaction.
@en
P2093
Donald D Ruhl
Jamie L Planck
John M Pascal
W Lee Kraus
P2860
P304
18877-18887
P356
10.1074/JBC.M110.105668
P407
P577
2010-04-13T00:00:00Z