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Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.Genomic structure and identification of a truncated variant message of the mouse estrogen receptor alpha gene.Contaminating cells alter gene signatures in whole organ versus laser capture microdissected tumors: a comparison of experimental breast cancers and their lymph node metastases.Identification of a stable molecular signature in mammary tumor endothelial cells that persists in vitro.Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasisTranscriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancerGenomic analysis identifies unique signatures predictive of brain, lung, and liver relapse.Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers.Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival.Vascular endothelial growth factor C promotes breast cancer progression via a novel antioxidant mechanism that involves regulation of superoxide dismutase 3.Differentiation and loss of malignant character of spontaneous pulmonary metastases in patient-derived breast cancer models.Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.Maintenance of hormone responsiveness in luminal breast cancers by suppression of NotchCIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer.SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancerHuman breast milk and xenoestrogen exposure: a possible impact on human health.A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts.Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways.αB-crystallin Expression in Breast Cancer is Associated with Brain Metastasis.Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signalingEndothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis.Taxonomy of breast cancer based on normal cell phenotype predicts outcome.HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth.Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes.Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium.The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB.Primary breast tumor-derived cellular models: characterization of tumorigenic, metastatic, and cancer-associated fibroblasts in dissociated tumor (DT) cultures.Separation of breast cancer and organ microenvironment transcriptomes in metastasesThyroid outcome during long-term gonadotropin-releasing hormone agonist treatments for idiopathic precocious pubertyCharacterizing the efficacy of cancer therapeutics in patient-derived xenograft models of metastatic breast cancerIdentification of synergistic drug combinations using breast cancer patient-derived xenograftsQuantitative assessment of breast cancer liver metastasis expansion with patient-derived xenograftsThe utility of the "Glowing Head" mouse for breast cancer metastasis research
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description
researcher
@en
wetenschapper
@nl
name
J Chuck Harrell
@en
J Chuck Harrell
@nl
type
label
J Chuck Harrell
@en
J Chuck Harrell
@nl
prefLabel
J Chuck Harrell
@en
J Chuck Harrell
@nl
P106
P31
P496
0000-0003-3541-8418