The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
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Direct role of Bardet-Biedl syndrome proteins in transcriptional regulationEpithelial-mesenchymal transition in cancer: parallels between normal development and tumor progressionMechanisms of TGFβ-Induced Epithelial-Mesenchymal TransitionThe retinal determination gene network: from developmental regulator to cancer therapeutic targetBreast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticityTargeting the Transforming Growth Factor-β Signaling in Cancer TherapyStructure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndromeThe dual regulatory role of miR-204 in cancerSwitching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker StudiesInterplay of retinal determination gene network with TGF-β signaling pathway in epithelial-mesenchymal transitionThe DACH/EYA/SIX gene network and its role in tumor initiation and progressionFighting the force: Potential of homeobox genes for tumor microenvironment regulationEpithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.Smad4-mediated TGF-beta signaling in tumorigenesis.Six1 expression is associated with a poor prognosis in patients with gliomaMicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma.Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes.Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitroEMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells.SFRP1 reduction results in an increased sensitivity to TGF-β signaling.The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas.SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast cancer cellsAn RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progressionIdentification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity.DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells.Cell fate determination factor Dachshund reprograms breast cancer stem cell function.Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progressionBmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancerSix1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression.Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT.Identification of an mRNP complex regulating tumorigenesis at the translational elongation stepHomeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression.The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway.Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth.Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progressionTGF-β signaling in breast cancer cell invasion and bone metastasis.The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
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P2860
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Six1 homeoprotein induces ...... increasing TGF-beta signaling
@en
The Six1 homeoprotein induces ...... increasing TGF-beta signaling.
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type
label
The Six1 homeoprotein induces ...... increasing TGF-beta signaling
@en
The Six1 homeoprotein induces ...... increasing TGF-beta signaling.
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prefLabel
The Six1 homeoprotein induces ...... increasing TGF-beta signaling
@en
The Six1 homeoprotein induces ...... increasing TGF-beta signaling.
@nl
P2093
P2860
P356
P1476
The Six1 homeoprotein induces ...... increasing TGF-beta signaling
@en
P2093
Alana L Welm
Anna E Barón
Dean Billheimer
Douglas S Micalizzi
Heide L Ford
Karen A Heichman
Kathryn B Horwitz
Kimberly L Christensen
Paul Jedlicka
Ricardo D Coletta
P2860
P304
P356
10.1172/JCI37815
P407
P577
2009-08-24T00:00:00Z