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Q40441385-6E042449-44EA-43E6-A031-405678076948
Q40441385-6E042449-44EA-43E6-A031-405678076948
BestRank
Statement
http://www.wikidata.org/entity/statement/Q40441385-6E042449-44EA-43E6-A031-405678076948
Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.
P2860
Q40441385-6E042449-44EA-43E6-A031-405678076948
BestRank
Statement
http://www.wikidata.org/entity/statement/Q40441385-6E042449-44EA-43E6-A031-405678076948
rank
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wasDerivedFrom
9a18a4a95d084aa7722fd4179bb09b8071a3cd18
P2860
Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.