%D8%A8%D8%B1%D9%88%D8%AA%D9%8A%D9%86_BRCA1_%D9%88%D9%85%D8%B1%D8%B6_%D8%A3%D9%84%D8%B2%D9%87%D8%A7%D9%8A%D9%85%D8%B1BRCA1Category:BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1BRCA1%E0%AE%AA%E0%AE%BF%E0%AE%86%E0%AE%B0%E0%AF%8D%E0%AE%9A%E0%AE%BF%E0%AE%8F1BRCA1%D8%A8%D8%B1%D8%B3%D8%A7_1Q17487737
about
p-S1387;S1423;S1524;S1547-BRCA1:p-T714;T734-BARD1p-5S-BRCA1:p-2T-BARD1Meiotic single-stranded DNA complexSynaptonemal Complex:BRCA1BRCA1:BARD1BRCA1; ATR; FANCD2; FANCI; ATM; MDC1; CHEK1; RAD51DSUMO1:BRCA1Formation of meiotic single-stranded DNA invasion complexBRCA1 is recruited to unsynapsed regionsBRCA1 forms a heterodimer with BARD1BRCA1 gene expression is inhibited by E2F6PIAS1;4 SUMOylates BRCA1 with SUMO1PIAS1;4 SUMOylates BRCA1 with SUMO2;3
P527
P688
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cellsSuppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexesFunctional link of BRCA1 and ataxia telangiectasia gene product in DNA damage responseRoles of BRCA1 and its interacting proteinsE2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkagesBRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible geneBRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylaseBRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1)BRCA1 affects global DNA methylation through regulation of DNMT1A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombinationIdentification of DBC1 as a transcriptional repressor for BRCA1BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retentionBRCA1 is an essential regulator of heart function and survival following myocardial infarctionA member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathwayThe UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic functionBRCA1 participates in DNA decatenationGrowth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activityRoles of BRCA1 in centrosome duplicationAbraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseRAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sitesUbiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responseTranscriptional regulation of BRCA1 expression by a metabolic switchLocalization of BRCA1 protein in breast cancer tissue and cell lines with mutationsBRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repairBRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activityThe BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitinBRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase ABRCA1 supports XIST RNA concentration on the inactive X chromosomeBRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogenMERIT40 facilitates BRCA1 localization and DNA damage repairNBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint controlBRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosisCCDC98 targets BRCA1 to DNA damage sitesIdentification of a RING protein that can interact in vivo with the BRCA1 gene productA novel role for BRCA1 in regulating breast cancer cell spreading and motilityDNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
P921
Q50250574-CD0ED729-4C08-4470-9A1D-ADEF0F99FA94Q50250625-0A5386F0-1878-4C9F-B7E8-BE5C53C7983EQ50251575-7D78AD67-8610-415F-A30A-9F600B66655CQ50251601-4EDFF373-4309-4046-B567-46953E17E3C9Q50253465-EBA9CB42-AE66-4228-AFEC-2D901C017CE8Q50258111-AE6DC25E-F543-4B28-B608-DC5B1686B405Q50268677-DC9DCB82-EAED-43CE-A441-C804EDA862AEQ50286348-036A27AB-D5E8-47C6-B53A-38605C00CE19Q50286358-F7ED8F98-E796-4972-BAE4-E81B1ED09A25Q50287337-24B4AEDA-D228-4F9B-B9C2-EDC865456525Q50290807-4AD9EB8C-25E1-4953-A549-8E8A208C5DF4Q50296414-826955D6-C0FD-4E90-893A-DE254EC03237Q50296416-85AD815B-BC5E-47F3-B57D-8C4BA09316D2
P527
Q22003975-47866DDC-BE0E-44C9-90BF-B4AD5D4200F3Q22254383-59C0E157-4896-4613-BB03-6AFEC392F496Q22254665-2B8D1D92-50FF-4A09-8016-B5AC3D5EEF40Q22254698-FA711F62-67C3-49EE-9DD5-57CE7DE8ADEFQ24293777-8181DF2B-EABA-4516-BADC-65E5DD8F1A0CQ24294911-FD43584B-C1FD-4332-8622-67F9D2406932Q24297921-FFEAC2B6-00D4-4EAB-B486-A9E875542F43Q24298165-FA2B8606-CDBC-4181-B4B2-282A9DC7E8BAQ24298913-5ED9A9E8-F653-44AD-A866-A6AA39F877BFQ24299584-71680CDC-04DF-4A62-80F4-6FB42A7772A2Q24299659-EB0EE78A-7113-48C7-AEEE-50FCFA9EA0D6Q24299844-8ECF668D-FD44-4D14-83AF-A3F8BAD15324Q24300290-4A83902A-DEEB-4117-A6A0-43E6E64DF1B3Q24301011-55F0F0D1-AD3F-4978-BE19-91BE44025EAEQ24305086-7C62A6D8-17DB-439E-A23A-23D3F3A24976Q24305584-0F665D7E-F6E4-4C57-AC06-8AE90E0CDE8EQ24306083-E3820C5A-A526-403E-A20F-9BECEA511E80Q24306201-5620CD96-D068-45A9-8A59-439958B49F89Q24306765-FC741888-E29E-41EC-BACC-0E83AF81699FQ24306789-ACD2B061-99D0-4BE9-AEEA-23E102C73A52Q24306807-F5B64490-113A-4D4B-BC67-F452D2944C65Q24307973-B6643C19-2C37-400B-8647-1F1F1755D919Q24308016-DAC226AB-6D07-481B-B846-A2B21F139F8DQ24310221-90E96411-D78E-4655-9E71-27B5E5588CEAQ24312783-F083D331-EEC2-4983-8B83-08B7CC8C2202Q24312959-BB276508-9A12-477F-888B-4FCED2BC28FEQ24315124-8FF256D8-5768-4119-880E-5BD95D0E7AB1Q24316340-EA0D8A3B-B96D-4EF3-84C4-B76E4578D7A4Q24316813-1195B62C-CBF7-401F-AD67-648AC10F56A5Q24317291-B09E9AAA-31A2-4273-87EA-D52C4B4D029AQ24317325-4C6F1F13-97C2-4E0D-AD17-4862EE5EBAC0Q24317553-9F1BC228-5E32-4166-B846-4D133F28826AQ24321418-5FA4AE55-128D-455B-BCB2-EDFD1A18D9BEQ24324342-437C48C5-AB31-4C4A-995E-4649E8C3DE7BQ24338824-2D0ED448-82B0-4645-84B1-4BBF0A8D2FDAQ52321036-68C802D9-9048-4D7E-A0EE-2B0DFAD51B14
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@da
protein
@id
protein
@sv
proteinë
@sq
proteïne in BRCA1, DNA repair associated
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
BRCA1 DNA repair associated
@en
BRCA1 DNA repair associated
@nl
BRCA1
@ca
BRCA1
@cy
BRCA1
@de
BRCA1
@es
BRCA1
@et
BRCA1
@fi
BRCA1
@fr
BRCA1
@gl
type
label
BRCA1 DNA repair associated
@en
BRCA1 DNA repair associated
@nl
BRCA1
@ca
BRCA1
@cy
BRCA1
@de
BRCA1
@es
BRCA1
@et
BRCA1
@fi
BRCA1
@fr
BRCA1
@gl
altLabel
BRCA1
@en
BRCA1/BRCA2-containing complex, subunit 1
@en
Fanconi anemia, complementation group S
@en
RING finger protein 53
@en
breast and ovarian cancer susceptibility protein 1
@en
breast cancer 1, early onset
@en
breast cancer type 1 susceptibility protein
@en
early onset breast cancer 1
@en
protein phosphatase 1, regulatory subunit 53
@en
prefLabel
BRCA1 DNA repair associated
@en
BRCA1 DNA repair associated
@nl
BRCA1
@ca
BRCA1
@cy
BRCA1
@de
BRCA1
@es
BRCA1
@et
BRCA1
@fi
BRCA1
@fr
BRCA1
@gl
P361
P527
P637
P638
P680
P681
P682
P705
P352
P486
P31
P352
P361
P486
P527
P637
P638
P680
P681
P682
P702
P703
P705
ENSP00000312236
ENSP00000326002
ENSP00000350283
ENSP00000397145
ENSP00000417148
ENSP00000417241
ENSP00000417554
ENSP00000417988
ENSP00000418212
ENSP00000418548