Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
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ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4Integration of Mitochondrial Targeting for Molecular Cancer TherapeuticsPyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and CancersIncreasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular AscorbateComprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastomaPro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase ModulationCurrent views on cell metabolism in SDHx-related pheochromocytoma and paragangliomaPyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas.Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenzaOverexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.O-GlcNAcylation: The Sweet Side of the Cancer.The pyruvate dehydrogenase complexes: structure-based function and regulation.Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines.MICU1 drives glycolysis and chemoresistance in ovarian cancer.Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancerA phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies.A potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cellsElucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonanceMetabolic programming and PDHK1 control CD4+ T cell subsets and inflammationPhase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity.Targeting of two aspects of metabolism in breast cancer treatment.MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth.Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.Emerging metabolic targets in the therapy of hematological malignancies.KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and GlycolysisGenetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancerOncogene-induced cellular senescence elicits an anti-Warburg effectDichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-γ pathway.The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility.Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.Regulation of pyruvate metabolism in metabolic-related diseases.Mitochondrial dynamics: biology and therapy in lung cancer.Metabolic modulation of cancer: a new frontier with great translational potential.Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.Cancer stem cell molecular reprogramming of the Warburg effect in glioblastomas: a new target gleaned from an old concept.
P2860
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P2860
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@ast
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en-gb
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@nl
type
label
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@ast
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en-gb
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@nl
prefLabel
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@ast
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en-gb
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@nl
P2860
P3181
P356
P1476
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
@en
P2093
Evangelos D Michelakis
Gopinath Sutendra
P2860
P3181
P356
10.3389/FONC.2013.00038
P407
P577
2013-01-01T00:00:00Z